Seroatlas · Human Serome Atlas

ZNF35

Zinc finger protein 35

Also known as: HF.10, HF10, Zfp105, ZNF35_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P13682
Gene
ZNF35
Ensembl
ENSG00000169981
Chromosome
3
Canonical length
527 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in cellular response to retinoic acid; regulation of transcription by RNA polymerase II; and spermatogenesis. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

527 residues, UniProt reviewed canonical sequence.

>P13682|ZNF35
     1  MTAELREAMA LAPWGPVKVK KEEEEEENFP GQASSQQVHS ENIKVWAPVQ GLQTGLDGSE
    61  EEEKGQNISW DMAVVLKATQ EAPAASTLGS YSLPGTLAKS EILETHGTMN FLGAETKNLQ
   121  LLVPKTEICE EAEKPLIISE RIQKADPQGP ELGEACEKGN MLKRQRIKRE KKDFRQVIVN
   181  DCHLPESFKE EENQKCKKSG GKYSLNSGAV KNPKTQLGQK PFTCSVCGKG FSQSANLVVH
   241  QRIHTGEKPF ECHECGKAFI QSANLVVHQR IHTGQKPYVC SKCGKAFTQS SNLTVHQKIH
   301  SLEKTFKCNE CEKAFSYSSQ LARHQKVHIT EKCYECNECG KTFTRSSNLI VHQRIHTGEK
   361  PFACNDCGKA FTQSANLIVH QRSHTGEKPY ECKECGKAFS CFSHLIVHQR IHTAEKPYDC
   421  SECGKAFSQL SCLIVHQRIH SGDLPYVCNE CGKAFTCSSY LLIHQRIHNG EKPYTCNECG
   481  KAFRQRSSLT VHQRTHTGEK PYECEKCGAA FISNSHLMRH HRTHLVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
6.8 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.8 nTPM
  • endometrium: 4.1 nTPM
  • colon: 3.8 nTPM
  • esophagus: 3.8 nTPM
  • heart muscle: 3.7 nTPM
  • adipose tissue: 3.6 nTPM

Single-cell type

  • other brain neurons: 13 nCPM
  • bergmann glia: 13 nCPM
  • oligodendrocyte progenitor cells: 13 nCPM
  • oligodendrocytes: 12 nCPM
  • late primary spermatocytes: 12 nCPM
  • astrocytes: 12 nCPM

Immune cell

  • NK-cell: 2.3 nTPM
  • naive B-cell: 2 nTPM
  • intermediate monocyte: 1.9 nTPM
  • myeloid DC: 1.8 nTPM
  • non-classical monocyte: 1.8 nTPM
  • classical monocyte: 1.7 nTPM

Brain region

  • cerebellum: 7.3 nTPM
  • white matter: 7 nTPM
  • midbrain: 6.5 nTPM
  • basal ganglia: 6.4 nTPM
  • medulla oblongata: 6.4 nTPM
  • cerebral cortex: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.04
gnomAD missense Z
1.36
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF35 as an antibody target. Whether an autoantibody or antibody against ZNF35 could matter depends on whether native ZNF35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF35. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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