Seroatlas · Human Serome Atlas

ZNF347

Zinc finger protein 347

Also known as: ZN347_HUMAN, ZNF1111

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SE7
Gene: ZNF347
Ensembl: ENSG00000197937
Chromosome: 19
Canonical length: 839 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Microtubules

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

839 residues, UniProt reviewed canonical sequence.

>Q96SE7|ZNF347
     1  MALTQGQVTF RDVAIEFSQE EWTCLDPAQR TLYRDVMLEN YRNLASLGIS CFDLSIISML
    61  EQGKEPFTLE SQVQIAGNPD GWEWIKAVIT ALSSEFVMKD LLHKGKSNTG EVFQTVMLER
   121  QESQDIEGCS FREVQKNTHG LEYQCRDAEG NYKGVLLTQE GNLTHGRDEH DKRDARNKLI
   181  KNQLGLSLQS HLPELQLFQY EGKIYECNQV EKSFNNNSSV SPPQQMPYNV KTHISKKYLK
   241  DFISSLLLTQ GQKANNWGSP YKSNGCGMVF PQNSHLASHQ RSHTKEKPYK CYECGKAFRT
   301  RSNLTTHQVI HTGEKRYKCN ECGKVFSRNS QLSQHQKIHT GEKPYKCNEC GKVFTQNSHL
   361  VRHRGIHTGE KPYKCNECGK AFRARSSLAI HQATHSGEKP YKCNECGKVF TQNSHLTNHW
   421  RIHTGEKPYK CNECGKAFGV RSSLAIHLVI HTGEKPYKCH ECGKVFRRNS HLARHQLIHT
   481  GEKPYKCNEC GKAFRAHSNL TTHQVIHTGE KPYKCNECGK VFTQNSHLAN HQRIHTGVKP
   541  YMCNECGKAF SVYSSLTTHQ VIHTGEKPYK CNECGKVFTQ NSHLARHRGI HTGEKPYKCN
   601  ECGKVFRHNS YLSRHQRIHT GEKPYKYNEY GKAFSEHSNL TTHQVIHTGE KPYKCNECGK
   661  VFTQNSHLAR HRRVHTGGKP YQCNECGKAF SQTSKLARHQ RVHTGEKPYE CNQCGKAFSV
   721  RSSLTTHQAI HTGKKPYKCN ECGKVFTQNS HLARHRGIHT GEKPYKCNEC GKAFSQTSKL
   781  ARHQRIHTGE KPYECGKPFS ICSSLTTHQT IHTGGKPYKC NVWKVLKSEF KPCKPSQNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF347 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 17 nTPM
retina: 14 nTPM
spleen: 8.9 nTPM
skin: 6.3 nTPM
thyroid gland: 6.3 nTPM
cerebellum: 6.1 nTPM

Single-cell type

vascular endothelial cells: 30 nCPM
adrenal cortex cells: 27 nCPM
lymphatic endothelial cells: 26 nCPM
oligodendrocytes: 25 nCPM
podocytes: 22 nCPM
thyrotrophs: 22 nCPM

Immune cell

neutrophil: 6 nTPM
basophil: 3.6 nTPM
NK-cell: 3.5 nTPM
naive B-cell: 2.9 nTPM
memory B-cell: 1.8 nTPM
naive CD4 T-cell: 1.8 nTPM

Brain region

cerebellum: 78 nTPM
white matter: 72 nTPM
hypothalamus: 57 nTPM
medulla oblongata: 57 nTPM
amygdala: 56 nTPM
cerebral cortex: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -1.21
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF347 as an antibody target. Whether an autoantibody or antibody against ZNF347 could matter depends on whether native ZNF347 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF347 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF347 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...