Seroatlas · Human Serome Atlas

ZNF345

Zinc finger protein 345

Also known as: HZF10, ZN345_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14585
Gene: ZNF345
Ensembl: ENSG00000251247
Chromosome: 19
Canonical length: 488 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

488 residues, UniProt reviewed canonical sequence.

>Q14585|ZNF345
     1  MENLTKHSIE CSSFRGDWEC KNQFERKQGS QEGHFSEMIF TPEDMPTFSI QHQRIHTDEK
    61  LLECKECGKD FSFVSVLVRH QRIHTGEKPY ECKECGKAFG SGANLAYHQR IHTGEKPFEC
   121  KECGKAFGSG SNLTHHQRIH TGEKPYECKE CGKAFSFGSG LIRHQIIHSG EKPYECKECG
   181  KSFSFESALI RHHRIHTGEK PYECIDCGKA FGSGSNLTQH RRIHTGEKPY ECKACGMAFS
   241  SGSALTRHQR IHTGEKPYIC NECGKAFSFG SALTRHQRIH TGEKPYVCKE CGKAFNSGSD
   301  LTQHQRIHTG EKPYECKECE KAFRSGSKLI QHQRMHTGEK PYECKECGKT FSSGSDLTQH
   361  HRIHTGEKPY ECKECGKAFG SGSKLIQHQL IHTGERPYEC KECGKSFSSG SALNRHQRIH
   421  TGEKPYECKE CGKAFYSGSS LTQHQRIHTG EKLYECKNCG KAYGRDSEFQ QHKKSHNGKK
   481  LCELETIN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF345 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
skin: 7.1 nTPM
lymph node: 6.1 nTPM
epididymis: 5.8 nTPM
ovary: 5.8 nTPM
breast: 5.4 nTPM

Single-cell type

late spermatids: 262 nCPM
early spermatids: 172 nCPM
choroid plexus epithelial cells: 71 nCPM
distal convoluted tubule cells: 68 nCPM
podocytes: 61 nCPM
oligodendrocytes: 56 nCPM

Immune cell

basophil: 11 nTPM
naive CD4 T-cell: 5.2 nTPM
naive CD8 T-cell: 4.3 nTPM
eosinophil: 4.1 nTPM
T-reg: 3.8 nTPM
memory CD4 T-cell: 3.7 nTPM

Brain region

cerebellum: 48 nTPM
hypothalamus: 43 nTPM
cerebral cortex: 39 nTPM
white matter: 38 nTPM
thalamus: 36 nTPM
amygdala: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF345 as an antibody target. Whether an autoantibody or antibody against ZNF345 could matter depends on whether native ZNF345 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF345 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF345 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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