Seroatlas · Human Serome Atlas

ZNF343

Zinc finger protein 343

Also known as: MGC10715, ZN343_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P1L6
Gene
ZNF343
Ensembl
ENSG00000088876
Chromosome
20
Canonical length
599 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

599 residues, UniProt reviewed canonical sequence.

>Q6P1L6|ZNF343
     1  MMLPYPSALG DQYWEEILLP KNGENVETMK KLTQNHKAKG LPSNDTDCPQ KKEGKAQIVV
    61  PVTFRDVTVI FTEAEWKRLS PEQRNLYKEV MLENYRNLLS LAEPKPEIYT CSSCLLAFSC
   121  QQFLSQHVLQ IFLGLCAENH FHPGNSSPGH WKQQGQQYSH VSCWFENAEG QERGGGSKPW
   181  SARTEERETS RAFPSPLQRQ SASPRKGNMV VETEPSSAQR PNPVQLDKGL KELETLRFGA
   241  INCREYEPDH NLESNFITNP RTLLGKKPYI CSDCGRSFKD RSTLIRHHRI HSMEKPYVCS
   301  ECGRGFSQKS NLSRHQRTHS EEKPYLCREC GQSFRSKSIL NRHQWTHSEE KPYVCSECGR
   361  GFSEKSSFIR HQRTHSGEKP YVCLECGRSF CDKSTLRKHQ RIHSGEKPYV CRECGRGFSQ
   421  NSDLIKHQRT HLDEKPYVCR ECGRGFCDKS TLIIHERTHS GEKPYVCGEC GRGFSRKSLL
   481  LVHQRTHSGE KHYVCRECRR GFSQKSNLIR HQRTHSNEKP YICRECGRGF CDKSTLIVHE
   541  RTHSGEKPYV CSECGRGFSR KSLLLVHQRT HSGEKHYVCR ECGRGFSHKS NLIRHQRTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF343 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
9.8 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 9.8 nTPM
  • blood vessel: 9.6 nTPM
  • skeletal muscle: 9.4 nTPM
  • colon: 9 nTPM
  • urinary bladder: 8.8 nTPM
  • endometrium: 8.5 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 20 nCPM
  • brain inhibitory neurons: 18 nCPM
  • brain excitatory neurons: 17 nCPM
  • other brain neurons: 15 nCPM
  • choroid plexus epithelial cells: 14 nCPM
  • oligodendrocytes: 14 nCPM

Immune cell

  • naive B-cell: 4.8 nTPM
  • naive CD8 T-cell: 4.7 nTPM
  • memory B-cell: 4 nTPM
  • naive CD4 T-cell: 4 nTPM
  • memory CD4 T-cell: 3.9 nTPM
  • plasmacytoid DC: 3.6 nTPM

Brain region

  • cerebellum: 21 nTPM
  • white matter: 19 nTPM
  • hypothalamus: 17 nTPM
  • cerebral cortex: 17 nTPM
  • hippocampal formation: 17 nTPM
  • basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0.01
gnomAD missense Z
0.14
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF343 as an antibody target. Whether an autoantibody or antibody against ZNF343 could matter depends on whether native ZNF343 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF343 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF343 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF343. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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