ZNF341

Protein identityUniProt · HPA

UniProt accession

Q9BYN7

Gene

ZNF341

Ensembl

ENSG00000131061

Chromosome

20

Canonical length

854 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nuclear bodies,Vesicles

OverviewNCBI Gene

Enables DNA binding activity and DNA-binding transcription activator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Implicated in hyper IgE recurrent infection syndrome 3. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

854 residues, UniProt reviewed canonical sequence.

>Q9BYN7|ZNF341
     1  MAQAIFEALE GMDNQTVLAV QSLLDGQGAV PDPTGQSVNA PPAIQPLDDE DVFLCGKCKK
    61  QFNSLPAFMT HKREQCQGNA PALATVSLAT NSIYPPSAAP TAVQQAPTPA NRQISTYITV
   121  PPSPLIQTLV QGNILVSDDV LMSAMSAFTS LDQPMPQGPP PVQSSLNMHS VPSYLTQPPP
   181  PPPPPPPLPP PPPPQPPPPP PQSLGPPGRP NPGGNGVVEV YSAAAPLAGS GTVEIQALGM
   241  QPYPPLEVPN QCVEPPVYPT PTVYSPGKQG FKPKGPNPAA PMTSATGGTV ATFDSPATLK
   301  TRRAKGARGL PEAAGKPKAQ KLKCSYCDKS FTKNFDLQQH IRSHTGEKPF QCIACGRAFA
   361  QKSNVKKHMQ THKVWPPGHS GGTVSRNSVT VQVMALNPSR QEDEESTGLG QPLPGAPQPQ
   421  ALSTAGEEEG DKPESKQVVL IDSSYLCQFC PSKFSTYFQL KSHMTQHKNE QVYKCVVKSC
   481  AQTFPKLDTF LEHIKSHQEE LSYRCHLCGK DFPSLYDLGV HQYSHSLLPQ HSPKKDNAVY
   541  KCVKCVNKYS TPEALEHHLQ TATHNFPCPH CQKVFPCERY LRRHLPTHGS GGRFKCQVCK
   601  KFFRREHYLK LHAHIHSGEK PYKCSVCESA FNRKDKLKRH MLIHEPFKKY KCPFSTHTGC
   661  SKEFNRPDKL KAHILSHSGM KLHKCALCSK SFSRRAHLAE HQRAHTGNYK FRCAGCAKGF
   721  SRHKYLKDHR CRLGPQKDKD LQTRRPPQRR AAPRSCGSGG RKVLTPLPDP LGLEELKDTG
   781  AGLVPEAVPG KPPFAEPDAV LSIVVGGAVG AETELVVPGH AEGLGSNLAL AELQAGAEGP
   841  CAMLAVPVYI QASE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF341 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

3.1 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF341.

Disease | AllUniProt

Conditions ZNF341 is implicated in, by any mechanism.

• Hyper-IgE syndrome 3, autosomal recessive, with recurrent infections (HIES3) MIM:618282

Disease | GeneticClinVar

28 pathogenic / likely-pathogenic of 726 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hyper-IgE recurrent infection syndrome 3, autosomal recessive
• Hyper-IgE recurrent infection syndrome 1, autosomal dominant

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.65

gnomAD pLI

0

gnomAD missense Z

1.51

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of DNA-templated transcription

Molecular functions

• DNA binding
• DNA-binding transcription activator activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger C2H2-type
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• C2H2-type zinc finger

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger