Seroatlas · Human Serome Atlas

ZNF34

Zinc finger protein 34

Also known as: KOX32, ZNF34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ26
Gene: ZNF34
Ensembl: ENSG00000196378
Chromosome: 8
Canonical length: 560 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>Q8IZ26|ZNF34
     1  MLLLLSDQLL LTALRKPNPQ AMAALFLSAP PQAEVTFEDV AVYLSREEWG RLGPAQRGLY
    61  RDVMLETYGN LVSLGVGPAG PKPGVISQLE RGDEPWVLDV QGTSGKEHLR VNSPALGTRT
   121  EYKELTSQET FGEEDPQGSE PVEACDHISK SEGSLEKLVE QRGPRAVTLT NGESSRESGG
   181  NLRLLSRPVP DQRPHKCDIC EQSFEQRSYL NNHKRVHRSK KTNTVRNSGE IFSANLVVKE
   241  DQKIPTGKKL HYCSYCGKTF RYSANLVKHQ RLHTEEKPYK CDECGKAFSQ SCEFINHRRM
   301  HSGEIPYRCD ECGKTFTRRP NLMKHQRIHT GEKPYKCGEC GKHFSAYSSL IYHQRIHTGE
   361  KPYKCNDCGK AFSDGSILIR HRRTHTGEKP FECKECGKGF TQSSNLIQHQ RIHTGEKPYK
   421  CNECEKAFIQ KTKLVEHQRS HTGEKPYECN DCGKVFSQST HLIQHQRIHT GEKPYKCSEC
   481  GKAFHNSSRL IHHQRLHHGE KPYRCSDCKK AFSQSTYLIQ HRRIHTGEKP YKCSECGKAF
   541  RHSSNMCQHQ RIHLREDFSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 19 nTPM
blood vessel: 15 nTPM
retina: 12 nTPM
ovary: 10 nTPM
cervix: 9.9 nTPM
colon: 9.6 nTPM

Single-cell type

early primary spermatocytes: 33 nCPM
breast myoepithelial cells: 23 nCPM
rod photoreceptor cells: 18 nCPM
late primary spermatocytes: 15 nCPM
vascular smooth muscle cells: 15 nCPM
pericytes: 15 nCPM

Immune cell

non-classical monocyte: 16 nTPM
eosinophil: 13 nTPM
myeloid DC: 10 nTPM
basophil: 8.3 nTPM
memory CD8 T-cell: 7.8 nTPM
naive B-cell: 7.5 nTPM

Brain region

cerebellum: 19 nTPM
white matter: 14 nTPM
pons: 12 nTPM
cerebral cortex: 12 nTPM
hypothalamus: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF34 as an antibody target. Whether an autoantibody or antibody against ZNF34 could matter depends on whether native ZNF34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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