Seroatlas · Human Serome Atlas

ZNF337

Zinc finger protein 337

Also known as: dJ694B14.1, ZN337_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3M9
Gene: ZNF337
Ensembl: ENSG00000130684
Chromosome: 20
Canonical length: 751 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles,Plasma membrane

OverviewNCBI Gene

This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

751 residues, UniProt reviewed canonical sequence.

>Q9Y3M9|ZNF337
     1  MGPQGARRQA FLAFGDVTVD FTQKEWRLLS PAQRALYREV TLENYSHLVS LGILHSKPEL
    61  IRRLEQGEVP WGEERRRRPG PCAGIYAEHV LRPKNLGLAH QRQQQLQFSD QSFQSDTAEG
   121  QEKEKSTKPM AFSSPPLRHA VSSRRRNSVV EIESSQGQRE NPTEIDKVLK GIENSRWGAF
   181  KCAERGQDFS RKMMVIIHKK AHSRQKLFTC RECHQGFRDE SALLLHQNTH TGEKSYVCSV
   241  CGRGFSLKAN LLRHQRTHSG EKPFLCKVCG RGYTSKSYLT VHERTHTGEK PYECQECGRR
   301  FNDKSSYNKH LKAHSGEKPF VCKECGRGYT NKSYFVVHKR IHSGEKPYRC QECGRGFSNK
   361  SHLITHQRTH SGEKPFACRQ CKQSFSVKGS LLRHQRTHSG EKPFVCKDCE RSFSQKSTLV
   421  YHQRTHSGEK PFVCRECGQG FIQKSTLVKH QITHSEEKPF VCKDCGRGFI QKSTFTLHQR
   481  THSEEKPYGC RECGRRFRDK SSYNKHLRAH LGEKRFFCRD CGRGFTLKPN LTIHQRTHSG
   541  EKPFMCKQCE KSFSLKANLL RHQWTHSGER PFNCKDCGRG FILKSTLLFH QKTHSGEKPF
   601  ICSECGQGFI WKSNLVKHQL AHSGKQPFVC KECGRGFNWK GNLLTHQRTH SGEKPFVCNV
   661  CGQGFSWKRS LTRHHWRIHS KEKPFVCQEC KRGYTSKSDL TVHERIHTGE RPYECQECGR
   721  KFSNKSYYSK HLKRHLREKR FCTGSVGEAS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF337 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 72 nTPM
ovary: 28 nTPM
prostate: 25 nTPM
cervix: 25 nTPM
fallopian tube: 25 nTPM
retina: 24 nTPM

Single-cell type

retinal ganglion cells: 66 nCPM
rod photoreceptor cells: 65 nCPM
brain excitatory neurons: 61 nCPM
bergmann glia: 60 nCPM
epicardial cells: 59 nCPM
somatotrophs: 58 nCPM

Immune cell

naive CD8 T-cell: 6.1 nTPM
naive CD4 T-cell: 5.2 nTPM
MAIT T-cell: 5 nTPM
gdT-cell: 4.6 nTPM
memory CD8 T-cell: 4.2 nTPM
NK-cell: 3.9 nTPM

Brain region

cerebellum: 37 nTPM
white matter: 29 nTPM
choroid plexus: 25 nTPM
cerebral cortex: 22 nTPM
amygdala: 22 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF337 as an antibody target. Whether an autoantibody or antibody against ZNF337 could matter depends on whether native ZNF337 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF337 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF337 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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