Seroatlas · Human Serome Atlas

ZNF334

Zinc finger protein 334

Also known as: bA179N14.1, ZN334_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCZ1
Gene: ZNF334
Ensembl: ENSG00000198185
Chromosome: 20
Canonical length: 680 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

680 residues, UniProt reviewed canonical sequence.

>Q9HCZ1|ZNF334
     1  MKMKKFQIPV SFQDLTVNFT QEEWQQLDPA QRLLYRDVML ENYSNLVSVG YHVSKPDVIF
    61  KLEQGEEPWI VEEFSNQNYP DIDDALEKNK EIQDKHLTQT VFFSNKTLIT ERENVFGKTL
   121  NLGMNSVPSR KMPYKCNPGG NSLKTNSEVI VAKKSKENRK IPDGYSGFGK HEKSHLGMKK
   181  YRYNPMRKAS NQNENLILHQ NIQILKQPFD YNKCGKTFFK RAILITQKGR QTERKPNECN
   241  ECRKTFSKRS TLIVHQRIHT GEKPYVCSDC RKTFRVKTSL TRHRRIHTGE RPYECSECRK
   301  TFIDKSALIV HQKIHGGEKS YECNECGKTF FRKSALAEHF RSHTGEKPYE CKECGNAFSK
   361  KSYLVVHQRT HRGEKPNECK ECGKTFFCQS ALTAHQRIHT GEKPYECSEC EKTFFCQSAL
   421  NVHRRSHTGE KPYECSQCGK FLCTKSALIA HQITHRGKKS YECNECGKFF CHKSTLTIHQ
   481  RTHTGEKHGV FNKCGRISIV KSNCSQCKRM NTKENLYECS EHGHAVSKNS HLIVHQRTIW
   541  ERPYECNECG RTYCRKSALT HHQRTHTGQR PYECNECGKT FCQKFSFVEH QRTHTGEKPY
   601  ECNECGKSFC HKSAFRVHRR IHTGEKPYEC NQCGKTYRRL WTLTEHQKIH TGEKPYECNK
   661  CEKTFRHKSN FLLHQKSHKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF334 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

retina: 14 nTPM
pituitary gland: 14 nTPM
cerebellum: 13 nTPM
choroid plexus: 12 nTPM
ovary: 12 nTPM
prostate: 11 nTPM

Single-cell type

breast lactating cells: 65 nCPM
pituitary stem cells: 61 nCPM
bergmann glia: 61 nCPM
pituicytes/fscs: 59 nCPM
corticotrophs: 53 nCPM
astrocytes: 50 nCPM

Immune cell

plasmacytoid DC: 1 nTPM
NK-cell: 0.8 nTPM
intermediate monocyte: 0.2 nTPM
memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 30 nTPM
medulla oblongata: 25 nTPM
midbrain: 22 nTPM
hypothalamus: 22 nTPM
choroid plexus: 21 nTPM
pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: -0.53
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF334 as an antibody target. Whether an autoantibody or antibody against ZNF334 could matter depends on whether native ZNF334 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF334 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF334 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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