Seroatlas · Human Serome Atlas

ZNF333

Zinc finger protein 333

Also known as: KIAA1806, ZN333_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JL9
Gene
ZNF333
Ensembl
ENSG00000160961
Chromosome
19
Canonical length
665 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q96JL9|ZNF333
     1  MESVTFEDVA VEFIQEWALL DSARRSLCKY RMLDQCRTLA SRGTPPCKPS CVSQLGQRAE
    61  PKATERGILR ATGVAWESQL KPEELPSMQD LLEEASSRDM QMGPGLFLRM QLVPSIEERE
   121  TPLTREDRPA LQEPPWSLGC TGLKAAMQIQ RVVIPVPTLG HRNPWVARDS AVPARDPAWL
   181  QEDKVEEEAM APGLPTACSQ EPVTFADVAV VFTPEEWVFL DSTQRSLYRD VMLENYRNLA
   241  SVADQLCKPN ALSYLEERGE QWTTDRGVLS DTCAEPQCQP QEAIPSQDTF TEILSIDVKG
   301  EQPQPGEKLY KYNELEKPFN SIEPLFQYQR IHAGEASCEC QEIRNSFFQS AHLIVPEKIR
   361  SGDKSYACNK CEKSFRYSSD LIRHEKTHTA EKCFDCQECG QAFKYSSNLR RHMRTHTGEK
   421  PFECSQCGKT FTRNFNLILH QRNHTGEKPY ECKDCGKAFN QPSSLRSHVR THTGEKPFEC
   481  SQCGKAFREH SSLKTHLRTH TREKPYECNQ CGKPFRTSTH LNVHKRIHTG EKLYECATCG
   541  QVLSRLSTLK SHMRTHTGEK PYVCQECGRA FSEPSSLRKH ARTHSGKKPY ACQECGRAFG
   601  QSSHLIVHVR THSAGRPYQC NQCEKAFRHS SSLTVHKRTH VGRETIRNGS LPLSMSHPYC
   661  GPLAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF333 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
7.6 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 7.6 nTPM
  • ovary: 7.2 nTPM
  • skeletal muscle: 7.2 nTPM
  • blood vessel: 6.5 nTPM
  • spleen: 6.5 nTPM
  • endometrium: 6.3 nTPM

Single-cell type

  • neutrophils: 55 nCPM
  • microglia: 35 nCPM
  • oligodendrocytes: 35 nCPM
  • leydig cells: 33 nCPM
  • fibro-adipogenic progenitors: 32 nCPM
  • rod photoreceptor cells: 31 nCPM

Immune cell

  • NK-cell: 14 nTPM
  • basophil: 8.4 nTPM
  • neutrophil: 6.3 nTPM
  • eosinophil: 5.3 nTPM
  • MAIT T-cell: 4.6 nTPM
  • non-classical monocyte: 4.5 nTPM

Brain region

  • white matter: 14 nTPM
  • cerebellum: 13 nTPM
  • pons: 11 nTPM
  • basal ganglia: 11 nTPM
  • cerebral cortex: 11 nTPM
  • thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0
gnomAD missense Z
0.82
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF333 as an antibody target. Whether an autoantibody or antibody against ZNF333 could matter depends on whether native ZNF333 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF333 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF333 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF333. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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