Seroatlas · Human Serome Atlas

ZNF331

Zinc finger protein 331

Also known as: RITA, ZN331_HUMAN, ZNF361, ZNF463

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQX6
Gene
ZNF331
Ensembl
ENSG00000130844
Chromosome
19
Canonical length
463 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>Q9NQX6|ZNF331
     1  MAQGLVTFAD VAIDFSQEEW ACLNSAQRDL YWDVMLENYS NLVSLDLESA YENKSLPTEK
    61  NIHEIRASKR NSDRRSKSLG RNWICEGTLE RPQRSRGRYV NQMIINYVKR PATREGTPPR
   121  THQRHHKENS FECKDCGKAF SRGYQLSQHQ KIHTGEKPYE CKECKKAFRW GNQLTQHQKI
   181  HTGEKPYECK DCGKAFRWGS SLVIHKRIHT GEKPYECKDC GKAFRRGDEL TQHQRFHTGE
   241  KDYECKDCGK TFSRVYKLIQ HKRIHSGEKP YECKDCGKAF ICGSSLIQHK RIHTGEKPYE
   301  CQECGKAFTR VNYLTQHQKI HTGEKPHECK ECGKAFRWGS SLVKHERIHT GEKPYKCTEC
   361  GKAFNCGYHL TQHERIHTGE TPYKCKECGK AFIYGSSLVK HERIHTGVKP YGCTECGKSF
   421  SHGHQLTQHQ KTHSGAKSYE CKECGKACNH LNHLREHQRI HNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF331 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
118 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 118 nTPM
  • ovary: 109 nTPM
  • pituitary gland: 68 nTPM
  • blood vessel: 60 nTPM
  • placenta: 51 nTPM
  • fallopian tube: 48 nTPM

Single-cell type

  • epicardial cells: 2,083 nCPM
  • somatotrophs: 1,561 nCPM
  • monocytes: 1,175 nCPM
  • mast cells: 1,137 nCPM
  • lactotrophs: 951 nCPM
  • innate lymphoid cells: 941 nCPM

Immune cell

  • naive CD4 T-cell: 16 nTPM
  • MAIT T-cell: 15 nTPM
  • T-reg: 12 nTPM
  • memory CD4 T-cell: 11 nTPM
  • naive B-cell: 10 nTPM
  • naive CD8 T-cell: 10 nTPM

Brain region

  • cerebellum: 126 nTPM
  • cerebral cortex: 63 nTPM
  • medulla oblongata: 63 nTPM
  • choroid plexus: 62 nTPM
  • thalamus: 61 nTPM
  • midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.98
gnomAD missense Z
2.08
DepMap mean gene effect
0.18
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF331 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF331 as an antibody target. Whether an autoantibody or antibody against ZNF331 could matter depends on whether native ZNF331 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF331 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF331 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF331. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...