Seroatlas · Human Serome Atlas

ZNF329

Zinc finger protein 329

Also known as: FLJ12586, ZN329_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UD4
Gene: ZNF329
Ensembl: ENSG00000181894
Chromosome: 19
Canonical length: 541 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>Q86UD4|ZNF329
     1  MRLKMTTRNF PEREVPCDVE VERFTREVPC LSSLGDGWDC ENQEGHLRQS ALTLEKPGTQ
    61  EAICEYPGFG EHLIASSDLP PSQRVLATNG FHAPDSNVSG LDCDPALPSY PKSYADKRTG
   121  DSDACGKGFN HSMEVIHGRN PVREKPYKYP ESVKSFNHFT SLGHQKIMKR GKKSYEGKNF
   181  ENIFTLSSSL NENQRNLPGE KQYRCTECGK CFKRNSSLVL HHRTHTGEKP YTCNECGKSF
   241  SKNYNLIVHQ RIHTGEKPYE CSKCGKAFSD GSALTQHQRI HTGEKPYECL ECGKTFNRNS
   301  SLILHQRTHT GEKPYRCNEC GKPFTDISHL TVHLRIHTGE KPYECSKCGK AFRDGSYLTQ
   361  HERTHTGEKP FECAECGKSF NRNSHLIVHQ KIHSGEKPYE CKECGKTFIE SAYLIRHQRI
   421  HTGEKPYGCN QCQKLFRNIA GLIRHQRTHT GEKPYECNQC GKAFRDSSCL TKHQRIHTKE
   481  TPYQCPECGK SFKQNSHLAV HQRLHSREGP SRCPQCGKMF QKSSSLVRHQ RAHLGEQPME
   541  T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF329 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 8.4 nTPM
retina: 7.8 nTPM
cerebellum: 7.3 nTPM
testis: 7.1 nTPM
bone marrow: 6 nTPM
cerebral cortex: 5.9 nTPM

Single-cell type

lactotrophs: 30 nCPM
choroid plexus epithelial cells: 29 nCPM
distal convoluted tubule cells: 28 nCPM
rod photoreceptor cells: 28 nCPM
megakaryocyte-erythroid progenitors: 25 nCPM
brain excitatory neurons: 24 nCPM

Immune cell

naive B-cell: 4.8 nTPM
naive CD4 T-cell: 4.3 nTPM
eosinophil: 4.1 nTPM
memory B-cell: 4.1 nTPM
NK-cell: 3.5 nTPM
basophil: 3 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 14 nTPM
white matter: 14 nTPM
choroid plexus: 13 nTPM
basal ganglia: 12 nTPM
pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF329 as an antibody target. Whether an autoantibody or antibody against ZNF329 could matter depends on whether native ZNF329 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF329 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF329 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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