Seroatlas · Human Serome Atlas

ZNF324B

Zinc finger protein 324B

Also known as: FLJ45850, Z324B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6AW86
Gene
ZNF324B
Ensembl
ENSG00000249471
Chromosome
19
Canonical length
544 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>Q6AW86|ZNF324B
     1  MTFEDVAVYF SQEEWGLLDT AQRALYRHVM LENFTLVTSL GLSTSRPRVV IQLERGEEPW
    61  VPSGKDMTLA RNTYGRLNSG SWSLTEDRDV SGEWPRAFPD TPPGMTTSVF PVADACHSVK
   121  SLQRQPGASP SQERKPTGVS VIYWERLLLG SRSDQASISL RLTSPLRPPK SSRPREKTFT
   181  EYRVPGRQPR TPERQKPCAQ EVPGRAFGNA SDLKAASGGR DRRMGAAWQE PHRLLGGQEP
   241  STWDELGEAL HAGEKSFECR ACSKVFVKSS DLLKHLRTHT GERPYECTQC GKAFSQTSHL
   301  TQHQRIHSGE TPYACPVCGK AFRHSSSLVR HQRIHTAEKS FRCSECGKAF SHGSNLSQHR
   361  KIHAGGRPYA CAQCGRRFCR NSHLIQHERT HTGEKPFVCA LCGAAFSQGS SLFLHQRVHT
   421  GEKPFACAQC GRSFSRSSNL TQHQLLHTGE RPFRCVDCGK GFAKGAVLLS HRRIHTGEKP
   481  FVCTQCGRAF RERPALLHHQ RIHTTEKTNA AAPDCTPGPG FLQGHHRKVR RGGKPSPVLK
   541  PAKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF324B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
3.6 nTPM

Expression across tissuesHPA

Tissue

  • skin: 3.6 nTPM
  • pancreas: 3.5 nTPM
  • spleen: 3.2 nTPM
  • cervix: 3.1 nTPM
  • cerebral cortex: 2.9 nTPM
  • ovary: 2.9 nTPM

Single-cell type

  • early primary spermatocytes: 11 nCPM
  • rod photoreceptor cells: 6 nCPM
  • retinal amacrine cells: 4.3 nCPM
  • retinal pigment epithelial cells: 4.3 nCPM
  • respiratory deuterosomal cells: 4.1 nCPM
  • thymic myoid cells: 4.1 nCPM

Immune cell

  • NK-cell: 4.1 nTPM
  • neutrophil: 0.7 nTPM
  • classical monocyte: 0.6 nTPM
  • gdT-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.6 nTPM
  • naive B-cell: 0.5 nTPM

Brain region

  • cerebellum: 15 nTPM
  • cerebral cortex: 14 nTPM
  • hippocampal formation: 12 nTPM
  • basal ganglia: 12 nTPM
  • white matter: 11 nTPM
  • hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF324B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF324B as an antibody target. Whether an autoantibody or antibody against ZNF324B could matter depends on whether native ZNF324B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF324B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF324B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF324B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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