Seroatlas · Human Serome Atlas

ZNF322

Zinc finger protein 322

Also known as: bA457M11.2, bA457M11.3, HCG12, ZN322_HUMAN, ZNF322A, ZNF388, ZNF489

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6U7Q0
Gene: ZNF322
Ensembl: ENSG00000181315
Chromosome: 6
Canonical length: 402 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q6U7Q0|ZNF322
     1  MYTSEEKCNQ RTQKRKIYNV CPRKGKKIFI HMHEIIQIDG HIYQCLECKQ NFCENLALIM
    61  CERTHTGEKP YKCDMCEKTF VQSSDLTSHQ RIHNYEKPYK CSKCEKSFWH HLALSGHQRT
   121  HAGKKFYTCD ICGKNFGQSS DLLVHQRSHT GEKPYLCSEC DKCFSRSTNL IRHRRTHTGE
   181  KPFKCLECEK AFSGKSDLIS HQRTHTGERP YKCNKCEKSY RHRSAFIVHK RVHTGEKPYK
   241  CGACEKCFGQ KSDLIVHQRV HTGEKPYKCL ECMRSFTRSA NLIRHQATHT HTFKCLEYEK
   301  SFNCSSDLIV HQRIHMEEKP HQWSACESGF LLGMDFVAQQ KMRTQTEELH YKYTVCDKSF
   361  HQSSALLQHQ TVHIGEKPFV CNVSEKGLEL SPPHASEASQ MS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF322 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 17 nTPM
ovary: 17 nTPM
endometrium: 15 nTPM
cervix: 14 nTPM
thyroid gland: 14 nTPM
prostate: 14 nTPM

Single-cell type

epididymal clear cells: 35 nCPM
basal prostatic cells: 33 nCPM
epididymal principal cells: 31 nCPM
gonadotrophs: 30 nCPM
corticotrophs: 30 nCPM
microglia: 28 nCPM

Immune cell

NK-cell: 18 nTPM
non-classical monocyte: 12 nTPM
memory B-cell: 11 nTPM
eosinophil: 11 nTPM
gdT-cell: 11 nTPM
naive CD8 T-cell: 9.1 nTPM

Brain region

white matter: 26 nTPM
medulla oblongata: 21 nTPM
hypothalamus: 21 nTPM
spinal cord: 21 nTPM
cerebellum: 21 nTPM
pons: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0.03
gnomAD missense Z: 1.82
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF322 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

POU5F1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF322 as an antibody target. Whether an autoantibody or antibody against ZNF322 could matter depends on whether native ZNF322 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF322 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF322 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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