Seroatlas · Human Serome Atlas

ZNF320

Zinc finger protein 320

Also known as: DKFZp686G16228, ZFPL, ZN320_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A2RRD8
Gene
ZNF320
Ensembl
ENSG00000182986
Chromosome
19
Canonical length
509 aa
Protein class
Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytoplasmic bodies

OverviewNCBI Gene

ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

509 residues, UniProt reviewed canonical sequence.

>A2RRD8|ZNF320
     1  MALSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMNTLSS
    61  TGQGNTEVIH TGTLQRQASY HIGAFCSQEI EKDIHDFVFQ WQEDETNDHE APMTEIKKLT
   121  SSTDRYDQRH AGNKPIKGQL ESRFHLHLRR HRRIHTGEKP YKCEECEKVF SCKSHLEIHR
   181  IIHTGEKPYK CKVCDKAFKH DSHLAKHTRI HRGDKHYTCN ECGKVFDQKA TLACHHRSHT
   241  GEKPYKCNEC GKTFSQTSHL VYHHRLHTGE KPYKCNECGK TFARNSVLVI HKAVHTAEKP
   301  YKCNECGKVF KQRATLAGHR RVHTGEKPYR CEECDKVFSR KSHLERHRRI HTGEKPYKCK
   361  VCDKAFRSDS RLAEHQRVHT GERPYTCNEC GKVFSTKAYL ACHQKLHTGE KLYECEECDK
   421  VYIRKSHLER HRRIHTGEKP HKCGDCGKAF NSPSHLIRHQ RIHTGQKSYK CHQCGKVFSL
   481  RSLLAEHQKI PFGDNCFKCN EYSKPSSIN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF320 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 12 nTPM
  • retina: 12 nTPM
  • urinary bladder: 12 nTPM
  • parathyroid gland: 11 nTPM
  • cerebellum: 11 nTPM
  • placenta: 10 nTPM

Single-cell type

  • endometrial luminal cells: 70 nCPM
  • endometrial glandular cells: 68 nCPM
  • urothelial cells: 54 nCPM
  • cardiomyocytes: 43 nCPM
  • adrenal medulla cells: 43 nCPM
  • endometrial ciliated cells: 42 nCPM

Immune cell

  • NK-cell: 7.6 nTPM
  • plasmacytoid DC: 3.5 nTPM
  • naive CD4 T-cell: 3.3 nTPM
  • neutrophil: 3.3 nTPM
  • naive CD8 T-cell: 3.2 nTPM
  • gdT-cell: 3 nTPM

Brain region

  • cerebellum: 31 nTPM
  • white matter: 27 nTPM
  • basal ganglia: 25 nTPM
  • choroid plexus: 24 nTPM
  • hypothalamus: 23 nTPM
  • cerebral cortex: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.46
gnomAD pLI
0.22
gnomAD missense Z
0.56
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF320 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF320 as an antibody target. Whether an autoantibody or antibody against ZNF320 could matter depends on whether native ZNF320 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF320 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF320 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF320. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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