Seroatlas · Human Serome Atlas

ZNF316

Zinc finger protein 316

Also known as: ENST00000305834, MZF-3, ZN316_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFI3
Gene: ZNF316
Ensembl: ENSG00000205903
Chromosome: 7
Canonical length: 1004 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1004 residues, UniProt reviewed canonical sequence.

>A6NFI3|ZNF316
     1  MAALHTTPDS PAAQLERAED GSECDPDQEE EEEEEEKGEE VQEVEEEEEE IVVEEEEEGV
    61  AEVVQDAQVE AVAEVEVEAD VEEEDVKEVL AEEECPALGT QERLSRGGDA KSPVLQEKGL
   121  QASRAPATPR DEDLEEEEEE EEDEDEDDLL TAGCQELVTF EDVAVYFSLE EWERLEADQR
   181  GLYQEVMQEN YGILVSLGYP IPKPDLIFRL EQGEEPWVPD SPRPEEGDIV TGVYTGAWFW
   241  TDDIEDHEEE DDEDFLAEVA EEENEPPGLW SAAYGVGDVP GTWGPDDSDS AQTPEGWGPD
   301  PGGLGVLADG SEAKPFLPGR EPGANLLSPW AFPAAVAPPA GRPETTCDVC GKVFPHRSRL
   361  AKHQRYHAAV KPFGCEECGK GFVYRSHLAI HQRTHTGEKP FPCPDCGKRF VYKSHLVTHR
   421  RIHTGERPYR CAFCGAGFGR RSYLVTHQRT HTGERPYPCS HCGRSFSQSS ALARHQAVHT
   481  ADRPHCCPDC GQAFRLRADF QRHRRGGGCA EAGGDGPRRE PGETAAAAGP EDTDPGPEGS
   541  EVGEADGEAE AAAEEREEAA VAAPTPSGKV DPAPERRFLE LGNGLGEGEG PSSHPLGFHF
   601  PVHPKSWLHP DSFPILGLPD FRERLPVDGR PLPAPLGGPL SLVEGTGLAC DPFGGGGAAG
   661  GGGGLRAFGP AIGGLLAEPA PAALAEEESP WICSDCGKTF GRRAALAKHQ RYHAGERPHR
   721  CADCGKSFVY GSHLARHRRT HTGERPFPCP ECGARFARGS HLAAHVRGHT GEKPFVCGVC
   781  GAGFSRRAHL TAHGRAHTGE RPYACGECGR RFGQSAALTR HQWAHAEEKP HRCPDCGKGF
   841  GHSSDFKRHR RTHTGEKPFR CADCGRGFAQ RSNLAKHRRG HTGERPFPCP ECGKRFSQRS
   901  VLVTHQRTHT GERPYACANC GRRFSQSSHL LTHMKTHRGA TAAPGSGSAP APAPKPEAAA
   961  KGPSSAGPGE RGSALLEFAG GTSFGSEHQA AFAGPSGAYR EGVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF316 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 25 nTPM
spleen: 23 nTPM
thyroid gland: 20 nTPM
parathyroid gland: 20 nTPM
bone marrow: 20 nTPM
cerebral cortex: 18 nTPM

Single-cell type

neutrophils: 55 nCPM
proximal tubule cells: 37 nCPM
epididymal principal cells: 27 nCPM
renal collecting duct intercalated cells: 24 nCPM
paneth cells: 23 nCPM
podocytes: 22 nCPM

Immune cell

basophil: 0.7 nTPM
plasmacytoid DC: 0.6 nTPM
NK-cell: 0.5 nTPM
neutrophil: 0.4 nTPM
classical monocyte: 0.3 nTPM
eosinophil: 0.3 nTPM

Brain region

medulla oblongata: 27 nTPM
cerebral cortex: 25 nTPM
amygdala: 24 nTPM
white matter: 23 nTPM
hippocampal formation: 22 nTPM
midbrain: 21 nTPM

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF316 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF316 as an antibody target. Whether an autoantibody or antibody against ZNF316 could matter depends on whether native ZNF316 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF316 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF316 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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