Seroatlas · Human Serome Atlas

ZNF302

Zinc finger protein 302

Also known as: ZN302_HUMAN, ZNF135L, ZNF140L, ZNF327

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NR11
Gene: ZNF302
Ensembl: ENSG00000089335
Chromosome: 19
Canonical length: 478 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the zinc-finger protein family. The encoded protein contains seven C2H2-type zinc fingers and a KRAB domain, but its function has yet to be determined. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q9NR11|ZNF302
     1  MSQVTFSDVA IDFSHEEWAC LDSAQRDLYK DVMVQNYENL VSVGLSVTKP YVIMLLEDGK
    61  EPWMMEKKLS KAYPFPLSHS VPASVNFGFS ALFEHCSEVT EIFELSELCV FWVLHFLSNS
   121  PNSTVEAFSR SKKKKKKKKK RQCFAFLIYF RLGIKMGKQG IINKEGYLYE DSPQPVTMEK
   181  VVKQSYEFSN SNKNLEYTEC DTFRSTFHSK STLSEPQNNS AEGNSHKYDI LKKNLSKKSV
   241  IKSERINGGK KLLNSNKSGA AFNQSKSLTL PQTCNREKIY TCSECGKAFG KQSILSRHWR
   301  IHTGEKPYEC RECGKTFSHG SSLTRHQISH SGEKPYKCIE CGKAFSHGSS LTNHQSTHTG
   361  EKPYECMNCG KSFSRVSLLI QHLRIHTQEK RYECRICGKA FIHSSSLIHH QKSHTGEKPY
   421  ECRECGKAFC CSSHLTQHQR IHSMKKKYEC NKCLKVFSSF SFLVQHQSIH TEEKPFEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF302 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

retina: 41 nTPM
cerebellum: 40 nTPM
skeletal muscle: 35 nTPM
tongue: 29 nTPM
ovary: 28 nTPM
spinal cord: 28 nTPM

Single-cell type

myonuclei: 181 nCPM
sertoli cells: 122 nCPM
leydig cells: 119 nCPM
rod photoreceptor cells: 116 nCPM
adrenal cortex cells: 109 nCPM
early primary spermatocytes: 103 nCPM

Immune cell

naive CD4 T-cell: 27 nTPM
naive B-cell: 23 nTPM
memory B-cell: 22 nTPM
naive CD8 T-cell: 20 nTPM
plasmacytoid DC: 20 nTPM
basophil: 19 nTPM

Brain region

white matter: 39 nTPM
cerebellum: 30 nTPM
basal ganglia: 29 nTPM
spinal cord: 28 nTPM
medulla oblongata: 27 nTPM
thalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: -0.51
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF302 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF302 as an antibody target. Whether an autoantibody or antibody against ZNF302 could matter depends on whether native ZNF302 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF302 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF302 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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