Seroatlas · Human Serome Atlas

ZNF300

Zinc finger protein 300

Also known as: ZN300_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RE9
Gene: ZNF300
Ensembl: ENSG00000145908
Chromosome: 5
Canonical length: 604 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

604 residues, UniProt reviewed canonical sequence.

>Q96RE9|ZNF300
     1  MMKSQGLVSF KDVAVDFTQE EWQQLDPSQR TLYRDVMLEN YSHLVSMGYP VSKPDVISKL
    61  EQGEEPWIIK GDISNWIYPD EYQADGRQDR KSNLHNSQSC ILGTVSFHHK ILKGVTRDGS
   121  LCSILKVCQG DGQLQRFLEN QDKLFRQVTF VNSKTVTEAS GHKYNPLGKI FQECIETDIS
   181  IQRFHKYDAF KKNLKPNIDL PSCYKSNSRK KPDQSFGGGK SSSQSEPNSN LEKIHNGVIP
   241  FDDNQCGNVF RNTQSLIQYQ NVETKEKSCV CVTCGKAFAK KSQLIVHQRI HTGKKPYDCG
   301  ACGKAFSEKF HLVVHQRTHT GEKPYDCSEC GKAFSQKSSL IIHQRVHTGE KPYECSECGK
   361  AFSQKSPLII HQRIHTGEKP YECRECGKAF SQKSQLIIHH RAHTGEKPYE CTECGKAFCE
   421  KSHLIIHKRI HTGEKPYKCA QCEEAFSRKT ELITHQLVHT GEKPYECTEC GKTFSRKSQL
   481  IIHQRTHTGE KPYKCSECGK AFCQKSHLIG HQRIHTGEKP YICTECGKAF SQKSHLPGHQ
   541  RIHTGEKPYI CAECGKAFSQ KSDLVLHQRI HTGERPYQCA ICGKAFIQKS QLTVHQRIHT
   601  VVKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF300 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

ovary: 9.7 nTPM
retina: 8.4 nTPM
endometrium: 6.9 nTPM
thyroid gland: 6.6 nTPM
cervix: 6.4 nTPM
kidney: 6 nTPM

Single-cell type

late primary spermatocytes: 11 nCPM
oligodendrocyte progenitor cells: 11 nCPM
proximal tubule cells: 9.5 nCPM
gastric progenitor cells: 9 nCPM
papillary tip epithelial cells: 7.5 nCPM
differentiating spermatogonia: 7 nCPM

Immune cell

naive B-cell: 1.3 nTPM
NK-cell: 0.5 nTPM
intermediate monocyte: 0.4 nTPM
eosinophil: 0.3 nTPM
myeloid DC: 0.3 nTPM
gdT-cell: 0.2 nTPM

Brain region

cerebellum: 5.9 nTPM
white matter: 5.1 nTPM
basal ganglia: 4.5 nTPM
midbrain: 4.5 nTPM
pons: 4.5 nTPM
medulla oblongata: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF300 as an antibody target. Whether an autoantibody or antibody against ZNF300 could matter depends on whether native ZNF300 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF300 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF300 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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