ZNF296

Protein identityUniProt · HPA

UniProt accession

Q8WUU4

Gene

ZNF296

Ensembl

ENSG00000170684

Chromosome

19

Canonical length

475 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Centrosome

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of dendrite development; regulation of transcription by RNA polymerase II; and spermatogenesis. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q8WUU4|ZNF296
     1  MSRRKAGSAP RRVEPAPAAN PDDEMEMQDL VIELKPEPDA QPQQAPRLGP FSPKEVSSAG
    61  RFGGEPHHSP GPMPAGAALL ALGPRNPWTL WTPLTPNYPD RQPWTDKHPD LLTCGRCLQT
   121  FPLEAITAFM DHKKLGCQLF RGPSRGQGSE REELKALSCL RCGKQFTVAW KLLRHAQWDH
   181  GLSIYQTESE APEAPLLGLA EVAAAVSAVV GPAAEAKSPR ASGSGLTRRS PTCPVCKKTL
   241  SSFSNLKVHM RSHTGERPYA CDQCPYACAQ SSKLNRHKKT HRQVPPQSPL MADTSQEQAS
   301  AAPPEPAVHA AAPTSTLPCS GGEGAGAAAT AGVQEPGAPG SGAQAGPGGD TWGAITTEQR
   361  TDPANSQKAS PKKMPKSGGK SRGPGGSCEF CGKHFTNSSN LTVHRRSHTG ERPYTCEFCN
   421  YACAQSSKLN RHRRMHGMTP GSTRFECPHC HVPFGLRATL DKHLRQKHPE AAGEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF296 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

9.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.33

gnomAD pLI

0.96

gnomAD missense Z

1.61

DepMap mean gene effect

-0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of dendrite development
• negative regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II
• spermatogenesis

Molecular functions

• DNA-binding transcription factor activity
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Zinc finger C2H2-type
• Zinc finger C2H2 superfamily
• Developmental and Hematopoietic Transcription Factors
• BCL-11A-like, CCHC zinc finger
• Zinc finger, C2H2 type
• BCL-11A-like CCHC zinc finger

KeywordsUniProt

• Isopeptide bond
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF296 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• KLF4