Seroatlas · Human Serome Atlas

ZNF292

Zinc finger protein 292

Also known as: bA393I2.3, KIAA0530, ZFP292, Zn-15, Zn-16, ZN292_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60281
Gene: ZNF292
Ensembl: ENSG00000188994
Chromosome: 6
Canonical length: 2723 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

2723 residues, UniProt reviewed canonical sequence.

>O60281|ZNF292
     1  MADEEAEQER LSCGEGGCVA ELQRLGERLQ ELELQLRESR VPAVEAATDY CQQLCQTLLE
    61  YAEKWKTSED PLPLLEVYTV AIQSYVKARP YLTSECENVA LVLERLALSC VELLLCLPVE
   121  LSDKQWEQFQ TLVQVAHEKL MENGSCELHF LATLAQETGV WKNPVLCTIL SQEPLDKDKV
   181  NEFLAFEGPI LLDMRIKHLI KTNQLSQATA LAKLCSDHPE IGIKGSFKQT YLVCLCTSSP
   241  NGKLIEEISE VDCKDALEMI CNLESEGDEK SALVLCTAFL SRQLQQGDMY CAWELTLFWS
   301  KLQQRVEPSI QVYLERCRQL SLLTKTVYHI FFLIKVINSE TEGAGLATCI ELCVKALRLE
   361  STENTEVKIS ICKTISCLLP DDLEVKRACQ LSEFLIEPTV DAYYAVEMLY NQPDQKYDEE
   421  NLPIPNSLRC ELLLVLKTQW PFDPEFWDWK TLKRQCLALM GEEASIVSSI DELNDSEVYE
   481  KVVDYQEESK ETSMNGLSGG VGANSGLLKD IGDEKQKKRE IKQLRERGFI SARFRNWQAY
   541  MQYCVLCDKE FLGHRIVRHA QKHYKDGIYS CPICAKNFNS KETFVPHVTL HVKQSSKERL
   601  AAMKPLRRLG RPPKITTTNE NQKTNTVAKQ EQRPIKKNSL YSTDFIVFND NDGSDDENDD
   661  KDKSYEPEVI PVQKPVPVNE FNCPVTFCKK GFKYFKNLIA HVKGHKDNED AKRFLEMQSK
   721  KVICQYCRRH FVSVTHLNDH LQMHCGSKPY ICIQMKCKAG FNSYAELLTH RKEHQVFRAK
   781  CMFPKCGRIF SEAYLLYDHE AQHYNTYTCK FTGCGKVYRS QGELEKHLDD HSTPPEKVLP
   841  PEAQLNSSGD SIQPSEVNQN TAENIEKERS MLPSENNIEN SLLADRSDAW DKSKAESAVT
   901  KQDQISASEL RQANGPLSNG LENPATTPLL QSSEVAVSIK VSLNQGIEDN FGKQENSTVE
   961  GSGEALVTDL HTPVEDTCND LCHPGFQERK EQDCFNDAHV TQNSLVNSET LKIGDLTPQN
  1021  LERQVNNLMT FSVQNQAAFQ NNLPTSKFEC GDNVKTSSNL YNLPLKTLES IAFVPPQSDL
  1081  SNSLGTPSVP PKAPVQKFSC QVEGCTRTYN SSQSIGKHMK TAHPDQYAAF KMQRKSKKGQ
  1141  KANNLNTPNN GKFVYFLPSP VNSSNPFFTS QTKANGNPAC SAQLQHVSPP IFPAHLASVS
  1201  TPLLSSMESV INPNITSQDK NEQGGMLCSQ MENLPSTALP AQMEDLTKTV LPLNIDSGSD
  1261  PFLPLPAESS SMSLFPSPAD SGTNSVFSQL ENNTNHYSSQ IEGNTNSSFL KGGNGENAVF
  1321  PSQVNVANNF SSTNAQQSAP EKVKKDRGRG PNGKERKPKH NKRAKWPAII RDGKFICSRC
  1381  YRAFTNPRSL GGHLSKRSYC KPLDGAEIAQ ELLQSNGQPS LLASMILSTN AVNLQQPQQS
  1441  TFNPEACFKD PSFLQLLAEN RSPAFLPNTF PRSGVTNFNT SVSQEGSEII KQALETAGIP
  1501  STFEGAEMLS HVSTGCVSDA SQVNATVMPN PTVPPLLHTV CHPNTLLTNQ NRTSNSKTSS
  1561  IEECSSLPVF PTNDLLLKTV ENGLCSSSFP NSGGPSQNFT SNSSRVSVIS GPQNTRSSHL
  1621  NKKGNSASKR RKKVAPPLIA PNASQNLVTS DLTTMGLIAK SVEIPTTNLH SNVIPTCEPQ
  1681  SLVENLTQKL NNVNNQLFMT DVKENFKTSL ESHTVLAPLT LKTENGDSQM MALNSCTTSI
  1741  NSDLQISEDN VIQNFEKTLE IIKTAMNSQI LEVKSGSQGA GETSQNAQIN YNIQLPSVNT
  1801  VQNNKLPDSS PFSSFISVMP TKSNIPQSEV SHKEDQIQEI LEGLQKLKLE NDLSTPASQC
  1861  VLINTSVTLT PTPVKSTADI TVIQPVSEMI NIQFNDKVNK PFVCQNQGCN YSAMTKDALF
  1921  KHYGKIHQYT PEMILEIKKN QLKFAPFKCV VPTCTKTFTR NSNLRAHCQL VHHFTTEEMV
  1981  KLKIKRPYGR KSQSENVPAS RSTQVKKQLA MTEENKKESQ PALELRAETQ NTHSNVAVIP
  2041  EKQLVEKKSP DKTESSLQVI TVTSEQCNTN ALTNTQTKGR KIRRHKKEKE EKKRKKPVSQ
  2101  SLEFPTRYSP YRPYRCVHQG CFAAFTIQQN LILHYQAVHK SDLPAFSAEV EEESEAGKES
  2161  EETETKQTLK EFRCQVSDCS RIFQAITGLI QHYMKLHEMT PEEIESMTAS VDVGKFPCDQ
  2221  LECKSSFTTY LNYVVHLEAD HGIGLRASKT EEDGVYKCDC EGCDRIYATR SNLLRHIFNK
  2281  HNDKHKAHLI RPRRLTPGQE NMSSKANQEK SKSKHRGTKH SRCGKEGIKM PKTKRKKKNN
  2341  LENKNAKIVQ IEENKPYSLK RGKHVYSIKA RNDALSECTS RFVTQYPCMI KGCTSVVTSE
  2401  SNIIRHYKCH KLSKAFTSQH RNLLIVFKRC CNSQVKETSE QEGAKNDVKD SDTCVSESND
  2461  NSRTTATVSQ KEVEKNEKDE MDELTELFIT KLINEDSTSV ETQANTSSNV SNDFQEDNLC
  2521  QSERQKASNL KRVNKEKNVS QNKKRKVEKA EPASAAELSS VRKEEETAVA IQTIEEHPAS
  2581  FDWSSFKPMG FEVSFLKFLE ESAVKQKKNT DKDHPNTGNK KGSHSNSRKN IDKTAVTSGN
  2641  HVCPCKESET FVQFANPSQL QCSDNVKIVL DKNLKDCTEL VLKQLQEMKP TVSLKKLEVH
  2701  SNDPDMSVMK DISIGKATGR GQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF292 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

retina: 25 nTPM
bone marrow: 23 nTPM
thymus: 14 nTPM
parathyroid gland: 13 nTPM
ovary: 11 nTPM
lymph node: 11 nTPM

Single-cell type

neutrophils: 889 nCPM
syncytiotrophoblasts: 585 nCPM
somatotrophs: 580 nCPM
thyrotrophs: 553 nCPM
endometrial glandular cells: 524 nCPM
neutrophil progenitors: 476 nCPM

Immune cell

neutrophil: 17 nTPM
basophil: 14 nTPM
naive B-cell: 12 nTPM
memory B-cell: 10 nTPM
T-reg: 10 nTPM
naive CD4 T-cell: 9.3 nTPM

Brain region

cerebellum: 57 nTPM
white matter: 40 nTPM
cerebral cortex: 40 nTPM
basal ganglia: 34 nTPM
hypothalamus: 33 nTPM
thalamus: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF292.

Disease | AllUniProt

Conditions ZNF292 is implicated in, by any mechanism.

Intellectual developmental disorder, autosomal dominant 64 (MRD64) MIM:619188

Disease | GeneticClinVar

105 pathogenic / likely-pathogenic of 874 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder, autosomal dominant 64
Neurodevelopmental disorder
Inborn genetic diseases
Intellectual disability
ZNF292-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 1.41
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF292 as an antibody target. Whether an autoantibody or antibody against ZNF292 could matter depends on whether native ZNF292 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF292 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF292 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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