Seroatlas · Human Serome Atlas

ZNF286B

Putative zinc finger protein 286B

Also known as: Z286B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG31
Gene: ZNF286B
Canonical length: 522 aa

OverviewNCBI Gene

No narrative summary is available for ZNF286B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>P0CG31|ZNF286B
     1  METDLAEMPE KGVLSSQDSP HFQEKSTEEG EVAALRLTAR SQAAAAAAAP GSRSLRGVHV
    61  PPPLHPAPAR EEIKSTCSLK ACFSLSLTLT YYRTAFLLST ENEGNLHFQC PSDVETRPQS
   121  KDSTSVQDFS KAESCKVAII DRLTRNSVYD SNLEAALECE NWLEKQQGNQ ERHLREMFTH
   181  MNSLSEETDH EHDVYWKSFN QKSVLITEDR VPKGSYAFHT LEKSLKQKSN LMKKQRTYKE
   241  KKPHKCNDCG ELFTCHSVHI QHQRVHTGEK PYTCNECGKS FSHRANLTKH QRTHTRILFE
   301  CRECKKTFTE SSSLATHQRI HVGERPYECN ECGKGFNRST HLVQHQLIHT GVRPYECNEC
   361  DKAFIHSSAL IKHQRTHTGE KPYKCQECGK AFSHCSSLTK HQRVHTGEKP YECSECGKTF
   421  SQSTHLVQHQ RIHTGEKPYE CSECGKTFSQ SSNFAKHQRI HIGKKPYKCS ECGKAFIHSS
   481  ALIQHQRTHT GEKPFRCNEC GKSFKCSSSL IRHQRVHTEE QP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF286B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.01

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF286B as an antibody target. Whether an autoantibody or antibody against ZNF286B could matter depends on whether native ZNF286B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF286B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF286B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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