Seroatlas · Human Serome Atlas

ZNF286A

Zinc finger protein 286A

Also known as: KIAA1874, Z286A_HUMAN, ZNF286

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HBT8
Gene
ZNF286A
Ensembl
ENSG00000187607
Chromosome
17
Canonical length
521 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

521 residues, UniProt reviewed canonical sequence.

>Q9HBT8|ZNF286A
     1  METDLAEMPE KGALSSQDSP HFQEKSTEEG EVAALRLTAR SQETVTFKDV AMDFTPEEWG
    61  KLDPAQRDVM LENYRNLVSL WLPVSKPESY NLENGKEPLK LERKAPKSSY SDMETRPQSK
   121  DSTSVQDFSK AESCKVAIID RLTRNSVYDS NLEAALECEN WLENQQGNQE RHLREMFTHM
   181  NSLSEETDHK HDVYWKSFNQ KSVLITEDRV PKGSYAFHTL EKSLKQKSNL MKKQRTYKEK
   241  KPHKCNDCGE LFTYHSVLIR HQRVHTGEKP YTCNECGKSF SHRANLTKHQ RTHTRILFEC
   301  SECKKTFTES SSLATHQRIH VGERPYECNE CGKGFNRSTH LVQHQLIHTG VKPYECNECD
   361  KAFIHSSALI KHQRTHTGEK PYKCQECGKA FSHCSSLTKH QRVHTGEKPY ECSECGKTFS
   421  QSTHLVQHQR IHTGEKPYEC NECGKTFSRS SNFAKHQRIH IGKKPYKCSE CGKAFIHSSA
   481  LIQHQRTHTG EKPFRCNECG KSFKCSSSLI RHQRVHTEEQ P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF286A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 15 nTPM
  • heart muscle: 15 nTPM
  • parathyroid gland: 14 nTPM
  • thymus: 12 nTPM
  • endometrium: 12 nTPM
  • retina: 11 nTPM

Single-cell type

  • late spermatids: 6.2 nCPM
  • early spermatids: 4.6 nCPM
  • respiratory ionocytes: 2.5 nCPM
  • medullary thymic epithelial cells: 2.4 nCPM
  • epididymal efferent duct ciliated cells: 2.1 nCPM
  • epididymal principal cells: 1.9 nCPM

Immune cell

  • T-reg: 11 nTPM
  • naive CD8 T-cell: 10 nTPM
  • naive CD4 T-cell: 9.5 nTPM
  • memory CD4 T-cell: 8.1 nTPM
  • MAIT T-cell: 7.6 nTPM
  • memory CD8 T-cell: 7.6 nTPM

Brain region

  • white matter: 30 nTPM
  • cerebellum: 27 nTPM
  • basal ganglia: 23 nTPM
  • medulla oblongata: 23 nTPM
  • pons: 22 nTPM
  • hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
0.77
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF286A as an antibody target. Whether an autoantibody or antibody against ZNF286A could matter depends on whether native ZNF286A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF286A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF286A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF286A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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