Seroatlas · Human Serome Atlas

ZNF283

Zinc finger protein 283

Also known as: ZN283_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N7M2
Gene
ZNF283
Ensembl
ENSG00000167637
Chromosome
19
Canonical length
679 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

679 residues, UniProt reviewed canonical sequence.

>Q8N7M2|ZNF283
     1  MESRSVAQAG VQWCDLGSLQ APPPGFTLFS CLSLLSSWDY SSGFSGFCAS PIEESHGALI
    61  SSCNSRTMTD GLVTFRDVAI DFSQEEWECL DPAQRDLYVD VMLENYSNLV SLDLESKTYE
   121  TKKIFSENDI FEINFSQWEM KDKSKTLGLE ASIFRNNWKC KSIFEGLKGH QEGYFSQMII
   181  SYEKIPSYRK SKSLTPHQRI HNTEKSYVCK ECGKACSHGS KLVQHERTHT AEKHFECKEC
   241  GKNYLSAYQL NVHQRFHTGE KPYECKECGK TFSWGSSLVK HERIHTGEKP YECKECGKAF
   301  SRGYHLTQHQ KIHTGVKSYK CKECGKAFFW GSSLAKHEII HTGEKPYKCK ECGKAFSRGY
   361  QLTQHQKIHT GKKPYECKIC GKAFCWGYQL TRHQIFHTGE KPYECKECGK AFNCGSSLIQ
   421  HERIHTGEKP YECKECGKAF SRGYHLSQHQ KIHTGEKPFE CKECGKAFSW GSSLVKHERV
   481  HTGEKSHECK ECGKTFCSGY QLTRHQVFHT GEKPYECKEC GKAFNCGSSL VQHERIHTGE
   541  KPYECKECGK AFSRGYHLTQ HQKIHTGEKP FKCKECGKAF SWGSSLVKHE RVHTNEKSYE
   601  CKDCGKAFGS GYQLSVHQRF HTGEKLYQRK EFGKTFTCGS KLVHERTHSN DKPYKYNECG
   661  EAFLWTTYSN EKIDTDETL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF283 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
7.7 nTPM

Expression across tissuesHPA

Tissue

  • retina: 7.7 nTPM
  • cerebellum: 5.3 nTPM
  • breast: 4.5 nTPM
  • tongue: 4.3 nTPM
  • skin: 4.2 nTPM
  • parathyroid gland: 4.1 nTPM

Single-cell type

  • tuft cells: 58 nCPM
  • somatotrophs: 31 nCPM
  • oligodendrocyte progenitor cells: 31 nCPM
  • corticotrophs: 30 nCPM
  • oligodendrocytes: 30 nCPM
  • lactotrophs: 29 nCPM

Immune cell

  • basophil: 2 nTPM
  • MAIT T-cell: 1.9 nTPM
  • naive CD4 T-cell: 1.8 nTPM
  • T-reg: 1.8 nTPM
  • memory CD4 T-cell: 1.7 nTPM
  • gdT-cell: 1.4 nTPM

Brain region

  • cerebellum: 26 nTPM
  • white matter: 24 nTPM
  • midbrain: 20 nTPM
  • basal ganglia: 19 nTPM
  • hippocampal formation: 19 nTPM
  • medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.99
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF283 as an antibody target. Whether an autoantibody or antibody against ZNF283 could matter depends on whether native ZNF283 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF283 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF283 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF283. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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