Seroatlas · Human Serome Atlas

ZNF282

Zinc finger protein 282

Also known as: HUB1, ZN282_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UDV7
Gene: ZNF282
Ensembl: ENSG00000170265
Chromosome: 7
Canonical length: 671 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

671 residues, UniProt reviewed canonical sequence.

>Q9UDV7|ZNF282
     1  MQFVSTRPQP QQLGIQGLGL DSGSWSWAQA LPPEEVCHQE PALRGEMAEG MPPMQAQEWD
    61  MDARRPMPFQ FPPFPDRAPV FPDRMMREPQ LPTAEISLWT VVAAIQAVER KVDAQASQLL
   121  NLEGRTGTAE KKLADCEKTA VEFGNHMESK WAVLGTLLQE YGLLQRRLEN LENLLRNRNF
   181  WVLRLPPGSK GEAPKVPVTF VDIAVYFSED EWKNLDEWQK ELYNNLVKEN YKTLMSLDAE
   241  GSVPKPDAPV QAEPREEPCV WEQRHPEERE IPMDPEAGAE PLVPAQDASS QVKREDTLCV
   301  RGQRGLEERA IPTESITDSP ISAQDLLSRI KQEEHQCVWD QQDLADRDIP TDPNSESLIS
   361  AHDILSWIKQ EEQPYPWGPR DSMDGELGLD SGPSDSLLMV KNPPPAPPQP QPQPQPPQPQ
   421  LQSQPQPQSL PPIAVAENPG GPPSRGLLDD GFQVLPGERG SGEAPPGGDR STGGGGGDGG
   481  GGGGGAEAGT GAGGGCGSCC PGGLRRSLLL HGARSKPYSC PECGKSFGVR KSLIIHHRSH
   541  TKERPYECAE CEKSFNCHSG LIRHQMTHRG ERPYKCSECE KTYSRKEHLQ NHQRLHTGER
   601  PFQCALCGKS FIRKQNLLKH QRIHTGERPY TCGECGKSFR YKESLKDHLR VHSGGPGPGA
   661  PRQLPPPPER D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF282 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

prostate: 18 nTPM
pancreas: 17 nTPM
skin: 16 nTPM
cerebellum: 16 nTPM
skeletal muscle: 16 nTPM
esophagus: 15 nTPM

Single-cell type

tuft cells: 46 nCPM
late spermatids: 42 nCPM
neutrophil progenitors: 38 nCPM
late primary spermatocytes: 38 nCPM
early spermatids: 28 nCPM
urothelial cells: 28 nCPM

Immune cell

naive B-cell: 1.7 nTPM
eosinophil: 1.1 nTPM
T-reg: 1.1 nTPM
memory CD4 T-cell: 0.7 nTPM
plasmacytoid DC: 0.7 nTPM
MAIT T-cell: 0.6 nTPM

Brain region

cerebellum: 22 nTPM
amygdala: 19 nTPM
white matter: 18 nTPM
cerebral cortex: 18 nTPM
medulla oblongata: 18 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.16
gnomAD missense Z: 2.14
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF282 as an antibody target. Whether an autoantibody or antibody against ZNF282 could matter depends on whether native ZNF282 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF282 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF282 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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