Seroatlas · Human Serome Atlas

ZNF280D

Zinc finger protein 280D

Also known as: FLJ20086, SUHW4, Z280D_HUMAN, ZNF634

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6N043
Gene: ZNF280D
Ensembl: ENSG00000137871
Chromosome: 15
Canonical length: 979 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus,Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

979 residues, UniProt reviewed canonical sequence.

>Q6N043|ZNF280D
     1  MGDNPFQPKS NSKMAELFME CEEEELEPWQ KKVKEVEDDD DDEPIFVGEI SSSKPAISNI
    61  LNRVNPSSYS RGLKNGALSR GITAAFKPTS QHYTNPTSNP VPASPINFHP ESRSSDSSVI
   121  VQPFSKPGYI TNSSRVVSNK SSELLFDLTQ DTGLSHYQGG PTLSMAGMSE SSFLSKRPST
   181  SEVNNVNPKK PKPSESVSGA NSSAVLPSVK SPSVTSSQAM LAKGTNTSSN QSKNGTPFPR
   241  ACPKCNIHFN LLDPLKNHMK YCCPDMINNF LGLAKTEFSS TVNKNTTIDS EKGKLIMLVN
   301  DFYYGKHEGD VQEEQKTHTT FKCFSCLKIL KNNIRFMNHM KHHLELEKQS SESWENHTTC
   361  QHCYRQFPTP FQLQCHIEST HTPHEFSTIC KICELSFETE HVLLQHMKDN HKPGEMPYVC
   421  QVCNYRSSSF SDVETHFRTS HENTKNLLCP FCLKVIKIAT PYMHHYMKHQ KKGIHRCTKC
   481  RLQFLTCKEK MDHKTQHHRT FIKPKQLEGL PPGTKVTIRA SVGPLQSGAS PTPSISASAS
   541  TLQLSPPRTK NITAKNPAKS NTSKPNTVKS NASKPNTSKP NGSKSKYKPK ISNMQKKQST
   601  LASSNKKSKV NTALRNLRYR RGIHKCIECC SEIKDFANHF PTYVHCSFCR YNTSCSKAYV
   661  NHMMSFHSNR PSKRFCIFKK HSENLRGITL VCLNCDFLSD VSGLDNMATH LSQHKTHTCQ
   721  VVMQKVSVCI PTSEHLSELK KEAPAKEQEP VSKEIARPNM AERETETSNS ESKQDKAASS
   781  KEKNGCNANS FEGSSTTKSE ESITVSDKEN ETCLADQETG SKNIVSCDSN IGADKVEKKK
   841  QIQHVCQEME LKMCQSSENI ILSDQIKDHN SSEARFSSKN IKDLRLASDN VSIDQFLRKR
   901  HEPESVSSDV SEQGSIHLEP LTPSEVLEYE ATEILQKGSG DPSAKTDEVV SDQTDDIPGG
   961  NNPSTTEATV DLEDEKERS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF280D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

thymus: 33 nTPM
bone marrow: 22 nTPM
ovary: 21 nTPM
endometrium: 19 nTPM
cervix: 17 nTPM
breast: 14 nTPM

Single-cell type

oligodendrocytes: 334 nCPM
bergmann glia: 308 nCPM
oligodendrocyte progenitor cells: 268 nCPM
choroid plexus epithelial cells: 253 nCPM
astrocytes: 224 nCPM
microglia: 203 nCPM

Immune cell

basophil: 8 nTPM
myeloid DC: 3.6 nTPM
plasmacytoid DC: 3.6 nTPM
eosinophil: 3.5 nTPM
memory B-cell: 3.5 nTPM
naive B-cell: 3.2 nTPM

Brain region

white matter: 29 nTPM
cerebellum: 28 nTPM
choroid plexus: 20 nTPM
cerebral cortex: 19 nTPM
spinal cord: 18 nTPM
hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.05
gnomAD missense Z: 1.18
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF280D as an antibody target. Whether an autoantibody or antibody against ZNF280D could matter depends on whether native ZNF280D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF280D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF280D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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