Seroatlas · Human Serome Atlas

ZNF280C

Zinc finger protein 280C

Also known as: FLJ20095, SUHW3, Z280C_HUMAN, ZNF633, ZPET

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8ND82
Gene: ZNF280C
Ensembl: ENSG00000056277
Chromosome: X
Canonical length: 737 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

737 residues, UniProt reviewed canonical sequence.

>Q8ND82|ZNF280C
     1  MDDDKPFQPK NISKMAELFM ECEEEELEPW QKKVEETQDE DDDELIFVGE ISSSKPAISN
    61  ILNRGHSSSS SKGIKSEPHS PGIPEIFRTA SQRCRDPPSN PVAASPRFHL VSKSSQSSVT
   121  VENASKPDFT KNSQVGSDNS SILLFDSTQE SLPPSQDIPA IFREGMKNTS YVLKHPSTSK
   181  VNSVTPKKPK TSEDVPQINP STSLPLIGSP PVTSSQVMLS KGTNTSSPYD AGADYLRACP
   241  KCNVQFNLLD PLKYHMKHCC PDMITKFLGV IVKSERPCDE DKTDSETGKL IMLVNEFYYG
   301  RHEGVTEKEP KTYTTFKCFS CSKVLKNNIR FMNHMKHHLE LEKQNNESWE NHTTCQHCYR
   361  QYPTPFQLQC HIESTHTPHE FSTICKICEL SFETEHILLQ HMKDTHKPGE MPYVCQVCQF
   421  RSSTFSDVEA HFRAAHENTK NLLCPFCLKV SKMATPYMNH YMKHQKKGVH RCPKCRLQFL
   481  TSKEKAEHKA QHRTFIKPKE LEGLPPGAKV TIRASLGPLQ SKLPTAPFGC APGTSFLQVT
   541  PPTSQNTTAR NPRKSNASRS KTSKLHATTS TASKVNTSKP RGRIAKSKAK PSYKQKRQRN
   601  RKNKMSLALK NIRCRRGIHK CIECHSKIKD FASHFSIYIH CSFCKYNTNC NKAFVNHMMS
   661  SHSNHPGKRF CIFKKHSGTL RGITLVCLKC DFLADSSGLD RMAKHLSQRK THTCQVIIEN
   721  VSKSTSTSEP TTGCSLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF280C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 8.8 nTPM

Expression across tissuesHPA

Tissue

testis: 8.8 nTPM
epididymis: 4.8 nTPM
endometrium: 2.5 nTPM
bone marrow: 2.4 nTPM
tonsil: 2.4 nTPM
cervix: 2.2 nTPM

Single-cell type

early primary spermatocytes: 65 nCPM
differentiating spermatogonia: 64 nCPM
retinal pigment epithelial cells: 38 nCPM
thymocytes: 35 nCPM
tuft cells: 35 nCPM
respiratory ionocytes: 33 nCPM

Immune cell

T-reg: 1.8 nTPM
MAIT T-cell: 1.7 nTPM
NK-cell: 1.7 nTPM
memory B-cell: 1.4 nTPM
naive CD8 T-cell: 1.3 nTPM
memory CD4 T-cell: 1.2 nTPM

Brain region

cerebellum: 6.9 nTPM
hypothalamus: 6.6 nTPM
cerebral cortex: 6.5 nTPM
white matter: 6.2 nTPM
basal ganglia: 5.7 nTPM
midbrain: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF280C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF280C as an antibody target. Whether an autoantibody or antibody against ZNF280C could matter depends on whether native ZNF280C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF280C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF280C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...