Seroatlas · Human Serome Atlas

ZNF280B

Zinc finger protein 280B

Also known as: 5'OY11.1, SUHW2, Z280B_HUMAN, ZNF279, ZNF632

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YH2
Gene: ZNF280B
Ensembl: ENSG00000275004
Chromosome: 22
Canonical length: 543 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q86YH2|ZNF280B
     1  MEQSCEEEKE PEPQKNIQET KQVDDEDAEL IFVGVEHVNE DAELIFVGVT SNSKPVVSNI
    61  LNRVTPGSWS RRKKYDHLRK DTARKLQPKS HETVTSEAVT VLPASQLESR STDSPIIIEP
   121  LSKPDYRNSS PQVVPNNSSE LPSPLITFTD SLHHPVSTAL SVGGINESPR VSKQLSTFEV
   181  NSINPKRAKL RDGIIEGNSS ASFPSDTFHT MNTQQSTPSN NVHTSLSHVQ NGAPFPAAFP
   241  KDNIHFKPIN TNLDRANELA KTDILSLTSQ NKTFDPKKEN PIVLLSDFYY GQHKGEGQPE
   301  QKTHTTFKCL SCVKVLKNVK FMNHVKHHLE FEKQRNDSWE NHTTCQHCHR QFPTPFQLQC
   361  HIENVHTAQE PSTVCKICEL SFETDQVLLQ HMKDHHKPGE MPYVCQVCHY RSSVFADVET
   421  HFRTCHENTK NLLCPFCLKI FKTATPYMCH YRGHWGKSAH QCSKCRLQFL TFKEKMEHKT
   481  QCHQMFKKPK QLEGLPPETK VTIQVSLEPL QPGSVDVASI TVSTSDSEPS LPRSKSKISK
   541  KSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF280B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
hypothalamus: 3.2 nTPM
retina: 3 nTPM
cerebral cortex: 2.6 nTPM
cerebellum: 2.5 nTPM
basal ganglia: 1.8 nTPM

Single-cell type

early spermatids: 33 nCPM
other brain neurons: 25 nCPM
late spermatids: 22 nCPM
brain inhibitory neurons: 21 nCPM
brain excitatory neurons: 20 nCPM
early primary spermatocytes: 17 nCPM

Immune cell

basophil: 11 nTPM
non-classical monocyte: 4.9 nTPM
NK-cell: 4.7 nTPM
naive CD8 T-cell: 4.3 nTPM
MAIT T-cell: 3.8 nTPM
neutrophil: 3.7 nTPM

Brain region

hypothalamus: 12 nTPM
cerebral cortex: 9.8 nTPM
midbrain: 9 nTPM
basal ganglia: 8 nTPM
pons: 8 nTPM
white matter: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.04
gnomAD missense Z: 0.13
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF280B as an antibody target. Whether an autoantibody or antibody against ZNF280B could matter depends on whether native ZNF280B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF280B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF280B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...