Seroatlas · Human Serome Atlas

ZNF280A

Zinc finger protein 280A

Also known as: 3'OY11.1, SUHW1, Z280A_HUMAN, ZNF280, ZNF636

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59817
Gene: ZNF280A
Ensembl: ENSG00000169548
Chromosome: 22
Canonical length: 542 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

542 residues, UniProt reviewed canonical sequence.

>P59817|ZNF280A
     1  MGDIFLCKKV ESPKKNLRES KQREEDDEDP DLIYVGVEHV HRDAEVLFVG MISNSKPVVS
    61  NILNRVTPGS NSRRKKGHFR QYPAHVSQPA NHVTSMAKAI MPVSLSEGRS TDSPVTMKSS
   121  SEPGYKMSSP QVVSPSSSDS LPPGTQCLVG AMVSGGGRNE SSPDSKRLST SDINSRDSKR
   181  VKLRDGIPGV PSLAVVPSDM SSTISTNTPS QGICNSSNHV QNGVTFPWPD ANGKAHFNLT
   241  DPERASESAL AMTDISSLAS QNKTFDPKKE NPIVLLSDFY YGQHKGDGQP EQKTHTTFKC
   301  LSCVKVLKNI KFMNHMKHHL EFEKQRNDSW EDHTTCQHCH RQFPTPFQLQ CHIDSVHIAM
   361  GPSAVCKICE LSFETDQVLL QHMKDHHKPG EMPYVCQVCH YRSSVFADVE THFRTCHENT
   421  KNLLCLFCLK LFKTAIPYMN HCWRHSRRRV LQCSKCRLQF LTLKEEIEHK TKDHQTFKKP
   481  EQLQGLPSET KVIIQTSVQP GSSGMASVIV SNTDPQSSPV KTKKKTAMNT RDSRLPCSKD
   541  SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF280A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 1.3 nTPM
testis: 0.2 nTPM
epididymis: 0.1 nTPM
adipose tissue: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

brain inhibitory neurons: 0.1 nCPM
distal convoluted tubule cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.1 nTPM
midbrain: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -0.56
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF280A as an antibody target. Whether an autoantibody or antibody against ZNF280A could matter depends on whether native ZNF280A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF280A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF280A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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