Seroatlas · Human Serome Atlas

ZNF28

Zinc finger protein 28

Also known as: DKFZp781D0275, KOX24, ZNF28_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P17035
Gene
ZNF28
Ensembl
ENSG00000198538
Chromosome
19
Canonical length
718 aa
Protein class
Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

718 residues, UniProt reviewed canonical sequence.

>P17035|ZNF28
     1  MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKTFFS
    61  TGQGNTEAFH TGTLQRQASH HIGDFCFQKI EKDIHGFQFQ WKEDETNDHA APMTEIKELT
   121  GSTGQHDQRH AGNKHIKDQL GLSFHSHLPE LHIFQPEGKI GNQVEKSINN ASSVSTSQRI
   181  CCRPKTHISN KYGNNSLHSS LLTQKRNVHM REKSFQCIES GKSFNCSSLL KKHQITHLEE
   241  KQCKCDVYGK VFNQKRYLAC HRRSHIDEKP YKCNECGKIF GHNTSLFLHK ALHTADKPYE
   301  CEECDKVFSR KSHLETHKII YTGGKPYKCK VCDKAFTCNS YLAKHTIIHT GEKPYKCNEC
   361  GKVFNRLSTL ARHRRLHTGE KPYECEECEK VFSRKSHLER HKRIHTGEKP YKCKVCDKAF
   421  AYNSYLAKHS IIHTGEKPYK CNECGKVFNQ QSTLARHHRL HTAEKPYKCE ECDKVFRCKS
   481  HLERHRRIHT GEKPYKCKVC DKAFRSDSCL TEHQRVHTGE KPYMCNECGK VFSTKANLAC
   541  HHKLHTAEKP YKCEECEKVF SRKSHMERHR RIHTGEKPYK CKVCDKAFRR DSHLAQHQRV
   601  HTGEKPYKCN ECGKTFRQTS SLIIHRRLHT GEKPYKCNEC GKTFSQMSSL VYHHRLHSGE
   661  KPYKCNECGK VFNQQAHLAQ HQRVHTGEKP YKCNECGKTF SQMSNLVYHH RLHSGEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
9.9 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 9.9 nTPM
  • rectum: 8 nTPM
  • thymus: 7.2 nTPM
  • fallopian tube: 7 nTPM
  • colon: 6.8 nTPM
  • breast: 6.7 nTPM

Single-cell type

  • enterocytes: 27 nCPM
  • megakaryocytes: 25 nCPM
  • paneth cells: 23 nCPM
  • ocular epithelial cells: 22 nCPM
  • gastric progenitor cells: 22 nCPM
  • foveolar cells: 21 nCPM

Immune cell

  • NK-cell: 25 nTPM
  • basophil: 21 nTPM
  • eosinophil: 9.3 nTPM
  • gdT-cell: 9.3 nTPM
  • naive CD8 T-cell: 8.7 nTPM
  • MAIT T-cell: 8.2 nTPM

Brain region

  • cerebellum: 14 nTPM
  • medulla oblongata: 9.7 nTPM
  • choroid plexus: 9.3 nTPM
  • white matter: 9 nTPM
  • hypothalamus: 8.9 nTPM
  • thalamus: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0.01
gnomAD missense Z
-1.23
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF28 as an antibody target. Whether an autoantibody or antibody against ZNF28 could matter depends on whether native ZNF28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF28 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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