Seroatlas · Human Serome Atlas

ZNF277

Zinc finger protein 277

Also known as: NRIF4, ZN277_HUMAN, ZNF277P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NRM2
Gene: ZNF277
Ensembl: ENSG00000198839
Chromosome: 7
Canonical length: 450 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and zinc ion binding activity. Predicted to act upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q9NRM2|ZNF277
     1  MAASKTQGAV ARMQEDRDGS CSTVGGVGYG DSKDCILEPL SLPESPGGTT TLEGSPSVPC
    61  IFCEEHFPVA EQDKLLKHMI IEHKIVIADV KLVADFQRYI LYWRKRFTEQ PITDFCSVIR
   121  INSTAPFEEQ ENYFLLCDVL PEDRILREEL QKQRLREILE QQQQERNDTN FHGVCMFCNE
   181  EFLGNRSVIL NHMAREHAFN IGLPDNIVNC NEFLCTLQKK LDNLQCLYCE KTFRDKNTLK
   241  DHMRKKQHRK INPKNREYDR FYVINYLELG KSWEEVQLED DRELLDHQED DWSDWEEHPA
   301  SAVCLFCEKQ AETIEKLYVH MEDAHEFDLL KIKSELGLNF YQQVKLVNFI RRQVHQCRCY
   361  GCHVKFKSKA DLRTHMEETK HTSLLPDRKT WDQLEYYFPT YENDTLLCTL SDSESDLTAQ
   421  EQNENVPIIS EDTSKLYALK QSSILNQLLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF277 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

liver: 11 nTPM
pancreas: 9.3 nTPM
kidney: 8.8 nTPM
thyroid gland: 8.8 nTPM
breast: 8.3 nTPM
heart muscle: 7.5 nTPM

Single-cell type

neutrophils: 327 nCPM
podocytes: 173 nCPM
monocytes: 164 nCPM
alveolar cells type 1: 163 nCPM
tuft cells: 115 nCPM
distal convoluted tubule cells: 111 nCPM

Immune cell

naive CD4 T-cell: 9.6 nTPM
naive B-cell: 9.5 nTPM
T-reg: 9.3 nTPM
basophil: 8.8 nTPM
memory B-cell: 8.7 nTPM
MAIT T-cell: 8.4 nTPM

Brain region

white matter: 23 nTPM
cerebral cortex: 20 nTPM
medulla oblongata: 19 nTPM
basal ganglia: 19 nTPM
thalamus: 19 nTPM
hippocampal formation: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF277 as an antibody target. Whether an autoantibody or antibody against ZNF277 could matter depends on whether native ZNF277 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF277 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF277 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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