Seroatlas · Human Serome Atlas

ZNF276

Zinc finger protein 276

Also known as: CENP-Z, CENPZ, MGC45417, ZADT, ZFP276, ZN276_HUMAN, ZNF477

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N554
Gene: ZNF276
Ensembl: ENSG00000158805
Chromosome: 16
Canonical length: 614 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in kinetochore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

614 residues, UniProt reviewed canonical sequence.

>Q8N554|ZNF276
     1  MKRDRLGRFL SPGSSRQCGA SDGGGGVSRT RGRPSLSGGP RVDGATARRA WGPVGSCGDA
    61  GEDGADEAGA GRALAMGHCR LCHGKFSSRS LRSISERAPG ASMERPSAEE RVLVRDFQRL
   121  LGVAVRQDPT LSPFVCKSCH AQFYQCHSLL KSFLQRVNAS PAGRRKPCAK VGAQPPTGAE
   181  EGACLVDLIT SSPQCLHGLV GWVHGHAASC GALPHLQRTL SSEYCGVIQV VWGCDQGHDY
   241  TMDTSSSCKA FLLDSALAVK WPWDKETAPR LPQHRGWNPG DAPQTSQGRG TGTPVGAETK
   301  TLPSTDVAQP PSDSDAVGPR SGFPPQPSLP LCRAPGQLGE KQLPSSTSDD RVKDEFSDLS
   361  EGDVLSEDEN DKKQNAQSSD ESFEPYPERK VSGKKSESKE AKKSEEPRIR KKPGPKPGWK
   421  KKLRCEREEL PTIYKCPYQG CTAVYRGADG MKKHIKEHHE EVRERPCPHP GCNKVFMIDR
   481  YLQRHVKLIH TEVRNYICDE CGQTFKQRKH LLVHQMRHSG AKPLQCEVCG FQCRQRASLK
   541  YHMTKHKAET ELDFACDQCG RRFEKAHNLN VHMSMVHPLT QTQDKALPLE AEPPPGPPSP
   601  SVTTEGQAVK PEPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF276 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

spleen: 26 nTPM
cerebellum: 23 nTPM
bone marrow: 20 nTPM
small intestine: 19 nTPM
esophagus: 19 nTPM
skin: 17 nTPM

Single-cell type

neutrophils: 95 nCPM
nk-cells: 56 nCPM
oligodendrocytes: 48 nCPM
oligodendrocyte progenitor cells: 46 nCPM
neutrophil progenitors: 41 nCPM
t-cells: 36 nCPM

Immune cell

gdT-cell: 6.7 nTPM
memory CD8 T-cell: 5.4 nTPM
naive CD8 T-cell: 4.9 nTPM
basophil: 3.9 nTPM
NK-cell: 3.8 nTPM
memory CD4 T-cell: 3.7 nTPM

Brain region

white matter: 35 nTPM
cerebral cortex: 29 nTPM
medulla oblongata: 27 nTPM
thalamus: 25 nTPM
basal ganglia: 24 nTPM
pons: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: -1.77
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
Zinc finger C2H2 superfamily
Zinc finger, C2H2 type
Zinc finger, AD-type
Zinc-finger associated domain (zf-AD)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF276 as an antibody target. Whether an autoantibody or antibody against ZNF276 could matter depends on whether native ZNF276 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF276 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF276 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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