Seroatlas · Human Serome Atlas

ZNF267

Zinc finger protein 267

Also known as: HZF2, ZN267_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14586
Gene
ZNF267
Ensembl
ENSG00000185947
Chromosome
16
Canonical length
743 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

743 residues, UniProt reviewed canonical sequence.

>Q14586|ZNF267
     1  MGLLTFRDVA VEFSLEEWEH LEPAQKNLYQ DVMLENYRNL VSLGLVVSKP DLITFLEQRK
    61  EPWNVKSEET VAIQPDVFSH YNKDLLTEHC TEASFQKVIS RRHGSCDLEN LHLRKRWKRE
   121  ECEGHNGCYD EKTFKYDQFD ESSVESLFHQ QILSSCAKSY NFDQYRKVFT HSSLLNQQEE
   181  IDIWGKHHIY DKTSVLFRQV STLNSYRNVF IGEKNYHCNN SEKTLNQSSS PKNHQENYFL
   241  EKQYKCKEFE EVFLQSMHGQ EKQEQSYKCN KCVEVCTQSL KHIQHQTIHI RENSYSYNKY
   301  DKDLSQSSNL RKQIIHNEEK PYKCEKCGDS LNHSLHLTQH QIIPTEEKPC KWKECGKVFN
   361  LNCSLYLTKQ QQIDTGENLY KCKACSKSFT RSSNLIVHQR IHTGEKPYKC KECGKAFRCS
   421  SYLTKHKRIH TGEKPYKCKE CGKAFNRSSC LTQHQTTHTG EKLYKCKVCS KSYARSSNLI
   481  MHQRVHTGEK PYKCKECGKV FSRSSCLTQH RKIHTGENLY KCKVCAKPFT CFSNLIVHER
   541  IHTGEKPYKC KECGKAFPYS SHLIRHHRIH TGEKPYKCKA CSKSFSDSSG LTVHRRTHTG
   601  EKPYTCKECG KAFSYSSDVI QHRRIHTGQR PYKCEECGKA FNYRSYLTTH QRSHTGERPY
   661  KCEECGKAFN SRSYLTTHRR RHTGERPYKC DECGKAFSYR SYLTTHRRSH SGERPYKCEE
   721  CGKAFNSRSY LIAHQRSHTR EKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF267 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 26 nTPM
  • appendix: 18 nTPM
  • tonsil: 17 nTPM
  • lymph node: 17 nTPM
  • urinary bladder: 13 nTPM
  • spleen: 12 nTPM

Single-cell type

  • neutrophils: 640 nCPM
  • monocytes: 280 nCPM
  • cdc: 154 nCPM
  • macrophages: 152 nCPM
  • esophageal apical cells: 95 nCPM
  • mast cells: 88 nCPM

Immune cell

  • neutrophil: 76 nTPM
  • basophil: 37 nTPM
  • eosinophil: 34 nTPM
  • non-classical monocyte: 28 nTPM
  • classical monocyte: 24 nTPM
  • intermediate monocyte: 24 nTPM

Brain region

  • cerebral cortex: 26 nTPM
  • thalamus: 15 nTPM
  • white matter: 12 nTPM
  • choroid plexus: 11 nTPM
  • pons: 11 nTPM
  • medulla oblongata: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0.02
gnomAD missense Z
0.57
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF267 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF267 as an antibody target. Whether an autoantibody or antibody against ZNF267 could matter depends on whether native ZNF267 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF267 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF267 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF267. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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