Seroatlas · Human Serome Atlas

ZNF26

Zinc finger protein 26

Also known as: FLJ20755, KOX20, ZNF26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17031
Gene: ZNF26
Ensembl: ENSG00000198393
Chromosome: 12
Canonical length: 533 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies,Mitochondria

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

533 residues, UniProt reviewed canonical sequence.

>P17031|ZNF26
     1  MATSFRTASC WGLLSFKDIS MEFTWDEWQL LDSTQKYLYR DVILENYHNL ISVGYHGTKP
    61  DLIFKLEQGE DPWIINAKIS RQSCPDGWEE WYQNNQDELE SIERSYACSV LGRLNLSKTH
   121  DSSRQRLYNT RGKSLTQNSA PSRSYLRKNP DKFHGYEEPY FLKHQRAHSI EKNCVCSECG
   181  KAFRCKSQLI VHLRIHTGER PYECSKCERA FSAKSNLNAH QRVHTGEKPY SCSECEKVFS
   241  FRSQLIVHQE IHTGGKPYGC SECGKAYSWK SQLLLHQRSH TGVKPYECSE CGKAFSLKSP
   301  FVVHQRTHTG VKPHKCSECG KAFRSKSYLL VHIRMHTGEK PYQCSDCGKA FNMKTQLIVH
   361  QGVHTGNNPY QCGECGKAFG RKEQLTAHLR AHAGEKPYGC SECGKAFSSK SYLVIHRRTH
   421  TGERPYECSL CERAFCGKSQ LIIHQRTHST EKPYECNECE KAYPRKASLQ IHQKTHSGEK
   481  PFKCSECGKA FTQKSSLSEH QRVHTGEKPW KCSECGKSFC WNSGLRIHRK THK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 1.5 nTPM
epididymis: 1.4 nTPM
skin: 1.3 nTPM
retina: 1.2 nTPM
skeletal muscle: 1.1 nTPM
cerebellum: 1 nTPM

Single-cell type

thymocytes: 53 nCPM
choroid plexus epithelial cells: 52 nCPM
proximal tubule cells: 43 nCPM
distal convoluted tubule cells: 41 nCPM
b-cells: 41 nCPM
renal connecting tubule cells: 40 nCPM

Immune cell

basophil: 6 nTPM
naive CD4 T-cell: 4.3 nTPM
gdT-cell: 4 nTPM
MAIT T-cell: 4 nTPM
naive B-cell: 3.8 nTPM
naive CD8 T-cell: 3.8 nTPM

Brain region

choroid plexus: 11 nTPM
cerebellum: 9.9 nTPM
white matter: 9.9 nTPM
cerebral cortex: 9.6 nTPM
hippocampal formation: 9.2 nTPM
hypothalamus: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF26 as an antibody target. Whether an autoantibody or antibody against ZNF26 could matter depends on whether native ZNF26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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