Seroatlas · Human Serome Atlas

ZNF256

Zinc finger protein 256

Also known as: BMZF-3, ZN256_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2P7
Gene: ZNF256
Ensembl: ENSG00000152454
Chromosome: 19
Canonical length: 627 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

627 residues, UniProt reviewed canonical sequence.

>Q9Y2P7|ZNF256
     1  MAAAELTAPA QGIVTFEDVA VYFSWKEWGL LDEAQKCLYH DVMLENLTLT TSLGGSGAGD
    61  EEAPYQQSTS PQRVSQVRIP KALPSPQKTN PCEICGPVLR QILHLVEHQG THHGQKLYTD
   121  GACRKQLQFT AYLHQHQKQH VGQKHFRSNG GRDMFLSSCT FEVSGKPFTC KEVGKDFLVR
   181  SRFLQQQAAH TRKKSNRTKS AVAFHSVKNH YNWGECVKAF SYKHVRVQHQ GDLIRERSYM
   241  CSECGKSFST SCSLSDHLRV HTSEKPYTCG ECGKSYRQSS SLITHRRIHT GVRPHQCDEC
   301  GKLFNRKYDL LIHQRVHTGE RPYKCSECGK SFSHSSSLIT HQRIHTGMRP YECSECGKSF
   361  IHSSSLITHQ RVHTGTRPYM CSECGKSFSQ SCHLIKHRRL HIGEGPYECS ECGKLFTYRS
   421  RFFQHQRVHT GVRSHECHEC GKLFSRKFDL IVHERVHTGE RPYECSECGK SFTCKSYLIS
   481  HWKVHTGARP YECGECGKSF THSSTLLQHQ RVHTGERPYE CNECGKFFSQ SSSLIRHRRS
   541  HTGERPYECS ECWKSFSNHS SLVKHRRVHT GERPYECSEC GKSFSQSSNL TNHQRIHSGE
   601  RPYECSDCGK FFTFNSNLLK HQNVHKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF256 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 10 nTPM
retina: 8.4 nTPM
skin: 6.8 nTPM
heart muscle: 5.7 nTPM
breast: 5.3 nTPM
ovary: 5 nTPM

Single-cell type

oocytes: 41 nCPM
medullary thymic epithelial cells: 9.6 nCPM
differentiating spermatogonia: 9.4 nCPM
mast cells: 8.3 nCPM
erythrocyte progenitors: 7.3 nCPM
b-cells: 7 nCPM

Immune cell

naive CD8 T-cell: 6.5 nTPM
MAIT T-cell: 6.1 nTPM
memory CD4 T-cell: 5.7 nTPM
naive B-cell: 5.6 nTPM
naive CD4 T-cell: 5.4 nTPM
memory CD8 T-cell: 5 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 8.9 nTPM
basal ganglia: 8.5 nTPM
choroid plexus: 8.4 nTPM
hippocampal formation: 8.4 nTPM
amygdala: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.01
gnomAD missense Z: -0.06
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF256 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF256 as an antibody target. Whether an autoantibody or antibody against ZNF256 could matter depends on whether native ZNF256 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF256 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF256 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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