Seroatlas · Human Serome Atlas

ZNF254

Zinc finger protein 254

Also known as: BMZF-5, HD-ZNF1, ZN254_HUMAN, ZNF539, ZNF91L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75437
Gene: ZNF254
Ensembl: ENSG00000213096
Chromosome: 19
Canonical length: 659 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

659 residues, UniProt reviewed canonical sequence.

>O75437|ZNF254
     1  MPGPPRSLEM GLLTFRDVAI EFSLEEWQHL DIAQQNLYRN VMLENYRNLA FLGIAVSKPD
    61  LITCLEQGKE PWNMKRHEMV DEPPGMCPHF AQDLWPEQGM EDSFQKAILR RYGKYGHENL
   121  QLRKGCKSVD EYKVNKEGYN GLNQCFTTAQ SKVFQCDKYL KVFYKFLNSN RPKIRHTEKK
   181  SFKCKKRVKL FCMLSHKTQH KSIYHREKSY KCKECGKTFN WSSTLTNHRK IYTEEKPYKC
   241  EEYNKSPKQL STLTTHEIIH AGEKLYKCEE CGEAFNRSSN LTTHKIIHTG EKPYKCEECG
   301  KAFIWSSTLT EHKKIHTRKK PYKCEECGKA FIWSSTLTRH KRMHTGEKPY KCEECGKAFS
   361  QSSTLTTHKI IHTGEKRYKC LECGKAFKQL STLTTHKIIH VGEKLYKCEE CGKGFNRSSN
   421  LTTHKIIHTG EKPYKCEECG KAFIWSSTLT KHKRIHTREK PYKCEECGKA FIWSSTLTRH
   481  KRMHTGEKPY KCEECGKSFS QSSTLTTHKI IHTGEKPYKC EECGKAFNWS STLTKHKIIH
   541  TEEKPYKCEK CGKAFKQSSI LTNHKRIHTG EKPYKCEECG KSFNRSSTFT KHKVIHTGVK
   601  PYKCEECGKA FFWSSTLTKH KRIHTGEQPY KWEKFGKAFN RSSHLTTDKI THWREILQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF254 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 16 nTPM
thymus: 11 nTPM
ovary: 10 nTPM
parathyroid gland: 10 nTPM
cervix: 8.5 nTPM
liver: 8.2 nTPM

Single-cell type

neutrophils: 257 nCPM
thymocytes: 192 nCPM
somatotrophs: 158 nCPM
bergmann glia: 152 nCPM
podocytes: 142 nCPM
thyrotrophs: 141 nCPM

Immune cell

basophil: 7.5 nTPM
eosinophil: 4.3 nTPM
memory B-cell: 3.4 nTPM
T-reg: 3.3 nTPM
naive B-cell: 3.2 nTPM
neutrophil: 3.2 nTPM

Brain region

cerebellum: 27 nTPM
hypothalamus: 23 nTPM
white matter: 21 nTPM
cerebral cortex: 19 nTPM
basal ganglia: 19 nTPM
midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0
gnomAD missense Z: -3.15
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF254 as an antibody target. Whether an autoantibody or antibody against ZNF254 could matter depends on whether native ZNF254 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF254 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF254 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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