Seroatlas · Human Serome Atlas

ZNF253

Zinc finger protein 253

Also known as: BMZF-1, FLJ90391, ZN253_HUMAN, ZNF411

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75346
Gene: ZNF253
Ensembl: ENSG00000256771
Chromosome: 19
Canonical length: 499 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

499 residues, UniProt reviewed canonical sequence.

>O75346|ZNF253
     1  MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR DVMLENYRNL VFLGIVVSKP DLVTCLEQGK
    61  KPLTMERHEM IAKPPVMSSH FAQDLWPENI QNSFQIGMLR RYEECRHDNL QLKKGCKSVG
   121  EHKVHKGGYN GLNQCLTTTQ KEIFQCDKYG KVFHKFSNSN TYKTRHTGIN LFKCIICGKA
   181  FKRSSTLTTH KKIHTGEKPY RCEECGKAFN QSANLTTHKR IHTGEKPYRC EECGKAFKQS
   241  SNLTTHKKIH TGEKPYKCEE CGKAFNRSTD LTTHKIVHTG EKPYKCEECG KAFKHPSHVT
   301  THKKIHTRGK PYNCEECGKS FKHCSNLTIH KRIHTGEKPY KCEECGKAFH LSSHLTTHKI
   361  LHTGEKPYRC RECGKAFNHS TTLFSHEKIH TGEKPYKCDE CGKTFTWPSI LSKHKRTHTG
   421  EKPYKCEECG KSFTASSTLT THKRIHTGEK PYKCEECGKA FNWSSDLNKH KKIHIERKPY
   481  IVKNVTDLLN VPPLLISIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF253 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

retina: 18 nTPM
thyroid gland: 14 nTPM
ovary: 12 nTPM
tongue: 9.8 nTPM
thymus: 8.4 nTPM
lymph node: 8 nTPM

Single-cell type

myonuclei: 113 nCPM
rod photoreceptor cells: 113 nCPM
cardiomyocytes: 73 nCPM
corticotrophs: 70 nCPM
oligodendrocytes: 51 nCPM
lactotrophs: 42 nCPM

Immune cell

naive CD4 T-cell: 15 nTPM
basophil: 13 nTPM
naive CD8 T-cell: 10 nTPM
naive B-cell: 9.4 nTPM
memory B-cell: 9 nTPM
memory CD8 T-cell: 7.7 nTPM

Brain region

cerebellum: 29 nTPM
white matter: 22 nTPM
hypothalamus: 22 nTPM
cerebral cortex: 21 nTPM
basal ganglia: 19 nTPM
thalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF253 as an antibody target. Whether an autoantibody or antibody against ZNF253 could matter depends on whether native ZNF253 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF253 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF253 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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