Seroatlas · Human Serome Atlas

ZNF251

Zinc finger protein 251

Also known as: ZN251_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRH9
Gene: ZNF251
Ensembl: ENSG00000198169
Chromosome: 8
Canonical length: 671 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic stem cell homeostasis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

671 residues, UniProt reviewed canonical sequence.

>Q9BRH9|ZNF251
     1  MAATFQLPGH QEMPLTFQDV AVYFSQAEGR QLGPQQRALY RDVMLENYGN VASLGFPVPK
    61  PELISQLEQG KELWVLNLLG AEEPDILKSC QKDSEVGTKK ELSILNQKFS EEVKTPEFVS
   121  RRLLRDNAQA AEFREAWGRE GKLKERVGNS AGQSLNKPNI HKRVLTEATV GRERSLGERT
   181  QECSAFDRNL NLDQNVVRLQ RNKTGERVFK CDICSKTFKY NSDLSRHQRS HTGEKPYECG
   241  RCGRAFTHSS NLVLHHHIHT GNKPFKCDEC GKTFGLNSHL RLHRRIHTGE KPFGCGECGK
   301  AFSRSSTLIQ HRIIHTGEKP YKCNECGRGF SQSPQLTQHQ RIHTGEKPHE CSHCGKAFSR
   361  SSSLIQHERI HTGEKPHKCN QCGKAFSQSS SLFLHHRVHT GEKPYVCNEC GRAFGFNSHL
   421  TEHVRIHTGE KPYVCNECGK AFRRSSTLVQ HRRVHTGEKP YQCVECGKAF SQSSQLTLHQ
   481  RVHTGEKPYD CGDCGKAFSR RSTLIQHQKV HSGETRKCRK HGPAFVHGSS LTADGQIPTG
   541  EKHGRAFNHG ANLILRWTVH TGEKSFGCNE YGKAFSPTSR PTEDQIMHAG EKPYKCQECG
   601  NAFSGKSTLI QHQVTHTGQK PCHCSVYGKA FSQSSQLTPP QQTRVGEKPA LNDGSKRYFI
   661  HIKKIFQERH F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF251 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 37 nTPM
thyroid gland: 28 nTPM
heart muscle: 24 nTPM
epididymis: 23 nTPM
pituitary gland: 22 nTPM
cervix: 22 nTPM

Single-cell type

proximal tubule cells: 79 nCPM
brain inhibitory neurons: 76 nCPM
brain excitatory neurons: 75 nCPM
distal convoluted tubule cells: 73 nCPM
renal connecting tubule cells: 71 nCPM
loop of henle epithelial cells: 67 nCPM

Immune cell

naive CD4 T-cell: 1.9 nTPM
T-reg: 1.6 nTPM
MAIT T-cell: 1.5 nTPM
memory B-cell: 1.4 nTPM
memory CD4 T-cell: 1.4 nTPM
memory CD8 T-cell: 1.4 nTPM

Brain region

cerebellum: 25 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 15 nTPM
hippocampal formation: 15 nTPM
white matter: 15 nTPM
amygdala: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF251 as an antibody target. Whether an autoantibody or antibody against ZNF251 could matter depends on whether native ZNF251 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF251 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF251 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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