Seroatlas · Human Serome Atlas

ZNF248

Zinc finger protein 248

Also known as: bA162G10.3, ZN248_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDW4
Gene: ZNF248
Ensembl: ENSG00000198105
Chromosome: 10
Canonical length: 579 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>Q8NDW4|ZNF248
     1  MNKSQEQVSF KDVCVDFTQE EWYLLDPAQK ILYRDVILEN YSNLVSVGYC ITKPEVIFKI
    61  EQGEEPWILE KGFPSQCHPE RKWKVDDVLE SSQENEDDHF WELLFHNNKT VSVENGDRGS
   121  KTFNLGTDPV SLRNYPYKIC DSCEMNLKNI SGLIISKKNC SRKKPDEFNV CEKLLLDIRH
   181  EKIPIGEKSY KYDQKRNAIN YHQDLSQPSF GQSFEYSKNG QGFHDEAAFF TNKRSQIGET
   241  VCKYNECGRT FIESLKLNIS QRPHLEMEPY GCSICGKSFC MNLRFGHQRA LTKDNPYEYN
   301  EYGEIFCDNS AFIIHQGAYT RKILREYKVS DKTWEKSALL KHQIVHMGGK SYDYNENGSN
   361  FSKKSHLTQL RRAHTGEKTF ECGECGKTFW EKSNLTQHQR THTGEKPYEC TECGKAFCQK
   421  PHLTNHQRTH TGEKPYECKQ CGKTFCVKSN LTEHQRTHTG EKPYECNACG KSFCHRSALT
   481  VHQRTHTGEK PFICNECGKS FCVKSNLIVH QRTHTGEKPY KCNECGKTFC EKSALTKHQR
   541  THTGEKPYEC NACGKTFSQR SVLTKHQRIH TRVKALSTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF248 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 30 nTPM
pituitary gland: 18 nTPM
colon: 17 nTPM
retina: 16 nTPM
cervix: 16 nTPM
seminal vesicle: 15 nTPM

Single-cell type

thyrotrophs: 279 nCPM
lactotrophs: 265 nCPM
somatotrophs: 245 nCPM
myonuclei: 212 nCPM
choroid plexus epithelial cells: 191 nCPM
retinal amacrine cells: 190 nCPM

Immune cell

naive CD4 T-cell: 6.1 nTPM
naive CD8 T-cell: 5.3 nTPM
naive B-cell: 5.2 nTPM
MAIT T-cell: 4.5 nTPM
memory B-cell: 4.2 nTPM
gdT-cell: 4 nTPM

Brain region

cerebellum: 54 nTPM
white matter: 45 nTPM
cerebral cortex: 44 nTPM
hypothalamus: 37 nTPM
basal ganglia: 36 nTPM
midbrain: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.33
gnomAD missense Z: 0.48
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF248 as an antibody target. Whether an autoantibody or antibody against ZNF248 could matter depends on whether native ZNF248 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF248 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF248 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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