Seroatlas · Human Serome Atlas

ZNF239

Zinc finger protein 239

Also known as: HOK-2, MOK2, ZN239_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16600
Gene: ZNF239
Ensembl: ENSG00000196793
Chromosome: 10
Canonical length: 458 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>Q16600|ZNF239
     1  MASTITGSQD CIVNHRGEVD GEPELDISPC QQWGEASSPI SRNRDSVMTL QSGCFENIES
    61  ETYLPLKVSS QIDTQDSSVK FCKNEPQDHQ ESRRLFVMEE STERKVIKGE SCSENLQVKL
   121  VSDGQELASP LLNGEATCQN GQLKESLDPI DCNCKDIHGW KSQVVSCSQQ RAHTEEKPCD
   181  HNNCGKILNT SPDGHPYEKI HTAEKQYECS QCGKNFSQSS ELLLHQRDHT EEKPYKCEQC
   241  GKGFTRSSSL LIHQAVHTDE KPYKCDKCGK GFTRSSSLLI HHAVHTGEKP YKCDKCGKGF
   301  SQSSKLHIHQ RVHTGEKPYE CEECGMSFSQ RSNLHIHQRV HTGERPYKCG ECGKGFSQSS
   361  NLHIHRCIHT GEKPYQCYEC GKGFSQSSDL RIHLRVHTGE KPYHCGKCGK GFSQSSKLLI
   421  HQRVHTGEKP YECSKCGKGF SQSSNLHIHQ RVHKKDPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF239 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

testis: 7.7 nTPM
breast: 5 nTPM
kidney: 5 nTPM
prostate: 4.9 nTPM
pancreas: 4.8 nTPM
smooth muscle: 4.5 nTPM

Single-cell type

late primary spermatocytes: 47 nCPM
early spermatids: 32 nCPM
late spermatids: 20 nCPM
oocytes: 14 nCPM
differentiating spermatogonia: 12 nCPM
alveolar cells type 1: 11 nCPM

Immune cell

naive CD4 T-cell: 6.4 nTPM
naive CD8 T-cell: 3.8 nTPM
MAIT T-cell: 3.7 nTPM
memory CD4 T-cell: 3.5 nTPM
naive B-cell: 2.8 nTPM
memory B-cell: 2.6 nTPM

Brain region

white matter: 5.5 nTPM
basal ganglia: 5.4 nTPM
cerebral cortex: 5.3 nTPM
hypothalamus: 5.2 nTPM
cerebellum: 5.1 nTPM
spinal cord: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF239 as an antibody target. Whether an autoantibody or antibody against ZNF239 could matter depends on whether native ZNF239 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF239 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF239 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...