Seroatlas · Human Serome Atlas

ZNF236

Zinc finger protein 236

Also known as: ZN236_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UL36
Gene: ZNF236
Ensembl: ENSG00000130856
Chromosome: 18
Canonical length: 1845 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cell Junctions,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to glucose stimulus. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1845 residues, UniProt reviewed canonical sequence.

>Q9UL36|ZNF236
     1  MGLCGLLERC WLHHDPDGVL TLNAENTNYA YQVPNFHKCE ICLLSFPKES QFQRHMRDHE
    61  RNDKPHRCDQ CPQTFNVEFN LTLHKCTHSG EDPTCPVCNK KFSRVASLKA HIMLHEKEEN
   121  LICSECGDEF TLQSQLAVHM EEHRQELAGT RQHACKACKK EFETSSELKE HMKTHYKIRV
   181  SSTRSYNRNI DRSGFTYSCP HCGKTFQKPS QLTRHIRIHT GERPFKCSEC GKAFNQKGAL
   241  QTHMIKHTGE KPHACAFCPA AFSQKGNLQS HVQRVHSEVK NGPTYNCTEC SCVFKSLGSL
   301  NTHISKMHMG GPQNSTSSTE TAHVLTATLF QTLPLQQTEA QATSASSQPS SQAVSDVIQQ
   361  LLELSEPAPV ESGQSPQPGQ QLSITVGINQ DILQQALENS GLSSIPAAAH PNDSCHAKTS
   421  APHAQNPDVS SVSNEQTDPT DAEQEKEQES PEKLDKKEKK MIKKKSPFLP GSIREENGVR
   481  WHVCPYCAKE FRKPSDLVRH IRIHTHEKPF KCPQCFRAFA VKSTLTAHIK THTGIKAFKC
   541  QYCMKSFSTS GSLKVHIRLH TGVRPFACPH CDKKFRTSGH RKTHIASHFK HTELRKMRHQ
   601  RKPAKVRVGK TNIPVPDIPL QEPILITDLG LIQPIPKNQF FQSYFNNNFV NEADRPYKCF
   661  YCHRAYKKSC HLKQHIRSHT GEKPFKCSQC GRGFVSAGVL KAHIRTHTGL KSFKCLICNG
   721  AFTTGGSLRR HMGIHNDLRP YMCPYCQKTF KTSLNCKKHM KTHRYELAQQ LQQHQQAASI
   781  DDSTVDQQSM QASTQMQVEI ESDELPQTAE VVAANPEAML DLEPQHVVGT EEAGLGQQLA
   841  DQPLEADEDG FVAPQDPLRG HVDQFEEQSP AQQSFEPAGL PQGFTVTDTY HQQPQFPPVQ
   901  QLQDSSTLES QALSTSFHQQ SLLQAPSSDG MNVTTRLIQE SSQEELDLQA QGSQFLEDNE
   961  DQSRRSYRCD YCNKGFKKSS HLKQHVRSHT GEKPYKCKLC GRGFVSSGVL KSHEKTHTGV
  1021  KAFSCSVCNA SFTTNGSLTR HMATHMSMKP YKCPFCEEGF RTTVHCKKHM KRHQTVPSAV
  1081  SATGETEGGD ICMEEEEEHS DRNASRKSRP EVITFTEEET AQLAKIRPQE SATVSEKVLV
  1141  QSAAEKDRIS ELRDKQAELQ DEPKHANCCT YCPKSFKKPS DLVRHVRIHT GEKPYKCDEC
  1201  GKSFTVKSTL DCHVKTHTGQ KLFSCHVCSN AFSTKGSLKV HMRLHTGAKP FKCPHCELRF
  1261  RTSGRRKTHM QFHYKPDPKK ARKPMTRSSS EGLQPVNLLN SSSTDPNVFI MNNSVLTGQF
  1321  DQNLLQPGLV GQAILPASVS AGGDLTVSLT DGSLATLEGI QLQLAANLVG PNVQISGIDA
  1381  ASINNITLQI DPSILQQTLQ QGNLLAQQLT GEPGLAPQNS SLQTSDSTVP ASVVIQPISG
  1441  LSLQPTVTSA NLTIGPLSEQ DSVLTTNSSG TQDLTQVMTS QGLVSPSGGP HEITLTINNS
  1501  SLSQVLAQAA GPTATSSSGS PQEITLTISE LNTTSGSLPS TTPMSPSAIS TQNLVMSSSG
  1561  VGGDASVTLT LADTQGMLSG GLDTVTLNIT SQGQQFPALL TDPSLSGQGG AGSPQVILVS
  1621  HTPQSASAAC EEIAYQVAGV SGNLAPGNQP EKEGRAHQCL ECDRAFSSAA VLMHHSKEVH
  1681  GRERIHGCPV CRKAFKRATH LKEHMQTHQA GPSLSSQKPR VFKCDTCEKA FAKPSQLERH
  1741  SRIHTGERPF HCTLCEKAFN QKSALQVHMK KHTGERPYKC AYCVMGFTQK SNMKLHMKRA
  1801  HSYAGALQES AGHPEQDGEE LSRTLHLEEV VQEAAGEWQA LTHVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF236 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

testis: 6.3 nTPM
bone marrow: 4.5 nTPM
thymus: 3.8 nTPM
ovary: 3.6 nTPM
skin: 3.5 nTPM
cerebellum: 3.4 nTPM

Single-cell type

lactotrophs: 85 nCPM
gonadotrophs: 84 nCPM
renal collecting duct intercalated cells: 83 nCPM
thyrotrophs: 80 nCPM
myonuclei: 80 nCPM
renal collecting duct principal cells: 77 nCPM

Immune cell

memory B-cell: 0.9 nTPM
T-reg: 0.7 nTPM
eosinophil: 0.5 nTPM
naive B-cell: 0.5 nTPM
naive CD4 T-cell: 0.4 nTPM
classical monocyte: 0.3 nTPM

Brain region

basal ganglia: 15 nTPM
cerebral cortex: 14 nTPM
hippocampal formation: 13 nTPM
white matter: 13 nTPM
cerebellum: 13 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.84
DepMap mean gene effect: -0.39
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF236 as an antibody target. Whether an autoantibody or antibody against ZNF236 could matter depends on whether native ZNF236 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF236 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF236 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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