Seroatlas · Human Serome Atlas

ZNF235

Zinc finger protein 235

Also known as: ANF270, HZF6, ZFP93, ZN235_HUMAN, ZNF270

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14590
Gene: ZNF235
Ensembl: ENSG00000159917
Chromosome: 19
Canonical length: 738 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger proteins, and contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the mouse Zfp93 protein. This gene is located in a cluster of zinc finger genes on 19q13.2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

738 residues, UniProt reviewed canonical sequence.

>Q14590|ZNF235
     1  MTKFQEAVTF KDVAVAFTEE ELGLLDSAQR KLYRDVMLEN FRNLVSVGHQ SFKPDMISQL
    61  EREEKLWMKE LQTQRGKHSG DRNQNEMATL HKAGLRCFSL GELSCWQIKR HIASKLARSQ
   121  DSMINIEGKS SQFPKHHDSP CQVGAGESIQ ASVDDNCLVN HIGDHSSIIE NQEFPTGKVP
   181  NSWSKIYLNE TQNYQRSCKQ TQMKNKLCIF APYVDIFSCI SHHHDDNIVH KRDKVHSNSD
   241  CGKDTLKVSP LTQRSIHTGQ KTYQGNECEE AFNDSSSLEL HKQVHLGKKS PACSTHEKDT
   301  SYSSGIPVQQ SVRTGKKRYW CHECGKGFSQ SSNLQTHQRV HTGEKPYTCH ECGKSFNQSS
   361  HLYAHLPIHT GEKPYRCDSC GKGFSRSTDL NIHCRVHTGE KPYKCEVCGK GFTQRSHLQA
   421  HERIHTGEKP YKCGDCGKRF SCSSNLHTHQ RVHTEEKPYK CDECGKCFSL SFNLHSHQRV
   481  HTGEKPYKCE ECGKGFSSAS SFQSHQRVHT GEKPFRCNVC GKGFSQSSYF QAHQRVHTGE
   541  KPYKCEVCGK RFNWSLNLHN HQRVHTGEKP YKCEECGKGF SQASNLQAHQ SVHTGEKPFK
   601  CDACQKRFSQ ASHLQAHQRV HTGEKPYKCD TCGKAFSQRS NLQVHQIIHT GEKPFKCEEC
   661  GKEFSWSAGL SAHQRVHTGE KPYTCQQCGK GFSQASHFHT HQRVHTGERP YICDVCCKGF
   721  SQRSHLIYHQ RVHTGGNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF235 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 4.2 nTPM

Expression across tissuesHPA

Tissue

thymus: 4.2 nTPM
cerebellum: 3.2 nTPM
tonsil: 3 nTPM
retina: 2.8 nTPM
tongue: 2.8 nTPM
lymph node: 2.6 nTPM

Single-cell type

cardiomyocytes: 148 nCPM
choroid plexus epithelial cells: 110 nCPM
ependymal cells: 110 nCPM
distal convoluted tubule cells: 89 nCPM
myonuclei: 89 nCPM
podocytes: 89 nCPM

Immune cell

basophil: 21 nTPM
naive B-cell: 10 nTPM
plasmacytoid DC: 8.1 nTPM
memory B-cell: 7 nTPM
naive CD4 T-cell: 6.8 nTPM
gdT-cell: 6.3 nTPM

Brain region

white matter: 8.5 nTPM
cerebral cortex: 7.6 nTPM
midbrain: 7.1 nTPM
hippocampal formation: 6.8 nTPM
pons: 6.6 nTPM
cerebellum: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF235 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF235 as an antibody target. Whether an autoantibody or antibody against ZNF235 could matter depends on whether native ZNF235 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF235 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF235 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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