Seroatlas · Human Serome Atlas

ZNF234

Zinc finger protein 234

Also known as: HZF4, ZN234_HUMAN, ZNF269

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14588
Gene: ZNF234
Ensembl: ENSG00000263002
Chromosome: 19
Canonical length: 700 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

700 residues, UniProt reviewed canonical sequence.

>Q14588|ZNF234
     1  MTTFKEGLTF KDVAVVFTEE ELGLLDPVQR NLYQDVMLEN FRNLLSVGHH PFKHDVFLLE
    61  KEKKLDIMKT ATQRKGKSAD KIQSEVETVP EAGRHEELYW GQIWKQIASD LIKYEDSMIS
   121  ISRFPRQGDL SCQVRAGLYT THTGQKFYQC DEYKKSFTDV FNFDLHQQLH SGEKSHTCDE
   181  CGKSFCYISA LHIHQRVHMG EKCYKCDVCG KEFSQSSHLQ THQRVHTVEK PFKCVECGKG
   241  FSRRSTLTVH CKLHSGEKPY NCEECGRAFI HASHLQEHQR IHTGEKPFKC DTCGKNFRRR
   301  SALNNHCMVH TGEKPYKCED CGKCFTCSSN LRIHQRVHTG EKPYKCEECG KCFIQPSQFQ
   361  AHRRIHTGEK PYVCKVCGKG FIYSSSFQAH QGVHTGEKPY KCNECGKSFR MKIHYQVHLV
   421  VHTGEKPYKC EVCGKAFRQS SYLKIHLKAH SVQKPFKCEE CGQGFNQSSR LQIHQLIHTG
   481  EKPYKCEECG KGFSRRADLK IHCRIHTGEK PYNCEECGKV FSQASHLLTH QRVHSGEKPF
   541  KCEECGKSFS RSAHLQAHQK VHTGEKPYKC GECGKGFKWS LNLDMHQRVH TGEKPYTCGE
   601  CGKHFSQASS LQLHQSVHTG EKPYKCDVCG KVFSRSSQLQ YHRRVHTGEK PYKCEICGKR
   661  FSWRSNLVSH HKIHAAGTFY ENDENSKNIR ELSEGGSSTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF234 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 5.4 nTPM

Expression across tissuesHPA

Tissue

spleen: 5.4 nTPM
retina: 4.9 nTPM
tonsil: 4.8 nTPM
adrenal gland: 4.5 nTPM
breast: 4.5 nTPM
thymus: 4.5 nTPM

Single-cell type

adrenal cortex cells: 28 nCPM
choroid plexus epithelial cells: 22 nCPM
bergmann glia: 20 nCPM
oligodendrocytes: 20 nCPM
hepatic stellate cells: 19 nCPM
medullary thymic epithelial cells: 19 nCPM

Immune cell

NK-cell: 4.4 nTPM
naive CD4 T-cell: 3.9 nTPM
naive CD8 T-cell: 3.8 nTPM
gdT-cell: 3.6 nTPM
naive B-cell: 3.4 nTPM
eosinophil: 3.1 nTPM

Brain region

white matter: 13 nTPM
cerebellum: 11 nTPM
choroid plexus: 11 nTPM
pons: 10 nTPM
basal ganglia: 9.7 nTPM
thalamus: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 1.15
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF234 as an antibody target. Whether an autoantibody or antibody against ZNF234 could matter depends on whether native ZNF234 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF234 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF234 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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