Seroatlas · Human Serome Atlas

ZNF229

Zinc finger protein 229

Also known as: ZN229_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJW7
Gene: ZNF229
Ensembl: ENSG00000278318
Chromosome: 19
Canonical length: 825 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

825 residues, UniProt reviewed canonical sequence.

>Q9UJW7|ZNF229
     1  METLTSRHEK RALHSQASAI SQDREEKIMS QEPLSFKDVA VVFTEEELEL LDSTQRQLYQ
    61  DVMQENFRNL LSVGERNPLG DKNGKDTEYI QDEELRFFSH KELSSCKIWE EVAGELPGSQ
   121  DCRVNLQGKD FQFSEDAAPH QGWEGASTPC FPIENFLDSL QGDGLIGLEN QQFPAWRAIR
   181  PIPIQGSWAK AFVNQLGDVQ ERCKNLDTED TVYKCNWDDD SFCWISCHVD HRFPEIDKPC
   241  GCNKCRKDCI KNSVLHRINP GENGLKSNEY RNGFRDDADL PPHPRVPLKE KLCQYDEFSE
   301  GLRHSAHLNR HQRVPTGEKS VKSLERGRGV RQNTHIRNHP RAPVGDMPYR CDVCGKGFRY
   361  KSVLLIHQGV HTGRRPYKCE ECGKAFGRSS NLLVHQRVHT GEKPYKCSEC GKGFSYSSVL
   421  QVHQRLHTGE KPYTCSECGK GFCAKSALHK HQHIHPGEKP YSCGECGKGF SCSSHLSSHQ
   481  KTHTGERPYQ CDKCGKGFSH NSYLQAHQRV HMGQHLYKCN VCGKSFSYSS GLLMHQRLHT
   541  GEKPYKCECG KSFGRSSDLH IHQRVHTGEK PYKCSECGKG FRRNSDLHSH QRVHTGERPY
   601  VCDVCGKGFI YSSDLLIHQR VHTGEKPYKC AECGKGFSYS SGLLIHQRVH TGEKPYRCQE
   661  CGKGFRCTSS LHKHQRVHTG KKPYTCDQCG KGFSYGSNLR THQRLHTGEK PYTCCECGKG
   721  FRYGSGLLSH KRVHTGEKPY RCHVCGKGYS QSSHLQGHQR VHTGEKPYKC EECGKGFGRN
   781  SCLHVHQRVH TGEKPYTCGV CGKGFSYTSG LRNHQRVHLG ENPYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF229 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

retina: 4.1 nTPM
parathyroid gland: 2.6 nTPM
ovary: 2 nTPM
thyroid gland: 1.9 nTPM
fallopian tube: 1.8 nTPM
adrenal gland: 1.6 nTPM

Single-cell type

choroid plexus epithelial cells: 20 nCPM
podocytes: 17 nCPM
bergmann glia: 15 nCPM
distal convoluted tubule cells: 14 nCPM
renal connecting tubule cells: 13 nCPM
other brain neurons: 12 nCPM

Immune cell

NK-cell: 1.5 nTPM
naive B-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
memory B-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

choroid plexus: 3.4 nTPM
white matter: 3 nTPM
cerebral cortex: 2.9 nTPM
thalamus: 2.9 nTPM
hypothalamus: 2.8 nTPM
hippocampal formation: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF229 as an antibody target. Whether an autoantibody or antibody against ZNF229 could matter depends on whether native ZNF229 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF229 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF229 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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