Seroatlas · Human Serome Atlas

ZNF227

Zinc finger protein 227

Also known as: ZN227_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WZ6
Gene: ZNF227
Ensembl: ENSG00000131115
Chromosome: 19
Canonical length: 799 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

799 residues, UniProt reviewed canonical sequence.

>Q86WZ6|ZNF227
     1  MPSQNYDLPQ KKQEKMTKFQ EAVTFKDVAV VFSREELRLL DLTQRKLYRD VMVENFKNLV
    61  AVGHLPFQPD MVSQLEAEEK LWMMETETQR SSKHQNKMET LQKFALKYLS NQELSCWQIW
   121  KQVASELTRC LQGKSSQLLQ GDSIQVSENE NNIMNPKGDS SIYIENQEFP FWRTQHSCGN
   181  TYLSESQIQS RGKQIDVKNN LQIHEDFMKK SPFHEHIKTD TEPKPCKGNE YGKIISDGSN
   241  QKLPLGEKPH PCGECGRGFS YSPRLPLHPN VHTGEKCFSQ SSHLRTHQRI HPGEKLNRCH
   301  ESGDCFNKSS FHSYQSNHTG EKSYRCDSCG KGFSSSTGLI IHYRTHTGEK PYKCEECGKC
   361  FSQSSNFQCH QRVHTEEKPY KCEECGKGFG WSVNLRVHQR VHRGEKPYKC EECGKGFTQA
   421  AHFHIHQRVH TGEKPYKCDV CGKGFSHNSP LICHRRVHTG EKPYKCEACG KGFTRNTDLH
   481  IHFRVHTGEK PYKCKECGKG FSQASNLQVH QNVHTGEKRF KCETCGKGFS QSSKLQTHQR
   541  VHTGEKPYRC DVCGKDFSYS SNLKLHQVIH TGEKPYKCEE CGKGFSWRSN LHAHQRVHSG
   601  EKPYKCEQCD KSFSQAIDFR VHQRVHTGEK PYKCGVCGKG FSQSSGLQSH QRVHTGEKPY
   661  KCDVCGKGFR YSSQFIYHQR GHTGEKPYKC EECGKGFGRS LNLRHHQRVH TGEKPHICEE
   721  CGKAFSLPSN LRVHLGVHTR EKLFKCEECG KGFSQSARLE AHQRVHTGEK PYKCDICDKD
   781  FRHRSRLTYH QKVHTGKKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF227 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

thymus: 16 nTPM
tonsil: 11 nTPM
ovary: 10 nTPM
cerebellum: 9.8 nTPM
parathyroid gland: 9.7 nTPM
lymph node: 9.6 nTPM

Single-cell type

cardiomyocytes: 62 nCPM
late spermatids: 33 nCPM
oocytes: 32 nCPM
bergmann glia: 29 nCPM
oligodendrocyte progenitor cells: 24 nCPM
myonuclei: 24 nCPM

Immune cell

basophil: 17 nTPM
T-reg: 14 nTPM
naive CD4 T-cell: 13 nTPM
naive B-cell: 12 nTPM
memory B-cell: 12 nTPM
NK-cell: 12 nTPM

Brain region

cerebellum: 28 nTPM
white matter: 25 nTPM
hypothalamus: 20 nTPM
midbrain: 20 nTPM
thalamus: 20 nTPM
basal ganglia: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF227 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF227 as an antibody target. Whether an autoantibody or antibody against ZNF227 could matter depends on whether native ZNF227 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF227 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF227 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...