Seroatlas · Human Serome Atlas

ZNF226

Zinc finger protein 226

Also known as: ZN226_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYT6
Gene: ZNF226
Ensembl: ENSG00000167380
Chromosome: 19
Canonical length: 803 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

803 residues, UniProt reviewed canonical sequence.

>Q9NYT6|ZNF226
     1  MNMFKEAVTF KDVAVAFTEE ELGLLGPAQR KLYRDVMVEN FRNLLSVGHP PFKQDVSPIE
    61  RNEQLWIMTT ATRRQGNLGE KNQSKLITVQ DRESEEELSC WQIWQQIAND LTRCQDSMIN
   121  NSQCHKQGDF PYQVGTELSI QISEDENYIV NKADGPNNTG NPEFPILRTQ DSWRKTFLTE
   181  SQRLNRDQQI SIKNKLCQCK KGVDPIGWIS HHDGHRVHKS EKSYRPNDYE KDNMKILTFD
   241  HNSMIHTGQK SYQCNECKKP FSDLSSFDLH QQLQSGEKSL TCVERGKGFC YSPVLPVHQK
   301  VHVGEKLKCD ECGKEFSQGA HLQTHQKVHV IEKPYKCKQC GKGFSRRSAL NVHCKVHTAE
   361  KPYNCEECGR AFSQASHLQD HQRLHTGEKP FKCDACGKSF SRNSHLQSHQ RVHTGEKPYK
   421  CEECGKGFIC SSNLYIHQRV HTGEKPYKCE ECGKGFSRPS SLQAHQGVHT GEKSYICTVC
   481  GKGFTLSSNL QAHQRVHTGE KPYKCNECGK SFRRNSHYQV HLVVHTGEKP YKCEICGKGF
   541  SQSSYLQIHQ KAHSIEKPFK CEECGQGFNQ SSRLQIHQLI HTGEKPYKCE ECGKGFSRRA
   601  DLKIHCRIHT GEKPYNCEEC GKVFRQASNL LAHQRVHSGE KPFKCEECGK SFGRSAHLQA
   661  HQKVHTGDKP YKCDECGKGF KWSLNLDMHQ RVHTGEKPYK CGECGKYFSQ ASSLQLHQSV
   721  HTGEKPYKCD VCGKVFSRSS QLQSHQRVHT GEKPYKCEIC GKSFSWRSNL TVHHRIHVGD
   781  KSYKSNRGGK NIRESTQEKK SIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF226 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 40 nTPM
pituitary gland: 31 nTPM
adrenal gland: 30 nTPM
retina: 29 nTPM
midbrain: 26 nTPM
epididymis: 24 nTPM

Single-cell type

epididymal principal cells: 70 nCPM
retinal pigment epithelial cells: 60 nCPM
esophageal apical cells: 56 nCPM
epididymal clear cells: 51 nCPM
cardiomyocytes: 47 nCPM
gastric progenitor cells: 45 nCPM

Immune cell

basophil: 54 nTPM
naive B-cell: 28 nTPM
T-reg: 27 nTPM
NK-cell: 27 nTPM
naive CD4 T-cell: 26 nTPM
MAIT T-cell: 25 nTPM

Brain region

white matter: 61 nTPM
cerebellum: 57 nTPM
cerebral cortex: 50 nTPM
choroid plexus: 48 nTPM
hypothalamus: 48 nTPM
basal ganglia: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -0.83
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF226 as an antibody target. Whether an autoantibody or antibody against ZNF226 could matter depends on whether native ZNF226 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF226 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF226 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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