Seroatlas · Human Serome Atlas

ZNF225

Zinc finger protein 225

Also known as: ZN225_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UK10
Gene: ZNF225
Ensembl: ENSG00000256294
Chromosome: 19
Canonical length: 706 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

706 residues, UniProt reviewed canonical sequence.

>Q9UK10|ZNF225
     1  MTTLKEAVTF KDVAVVFTEE ELRLLDLAQR KLYREVMLEN FRNLLSVGHQ SLHRDTFHFL
    61  KEEKFWMMET ATQREGNLGG KIQMEMETVS ESGTHEGLFS HQTWEQISSD LTRFQDSMVN
   121  SFQFSKQDDM PCQVDAGLSI IHVRQKPSEG RTCKKSFSDV SVLDLHQQLQ SREKSHTCDE
   181  CGKSFCYSSA LRIHQRVHMG EKLYNCDVCG KEFNQSSHLQ IHQRIHTGEK PFKCEQCGKG
   241  FSRRSGLYVH RKLHTGVKPH ICEKCGKAFI HDSQLQEHQR IHTGEKPFKC DICCKSFRSR
   301  ANLNRHSMVH MREKPFRCDT CGKSFGLKSA LNSHRMVHTG EKRYKCEECG KRFIYRQDLY
   361  KHQIDHTGEK PYNCKECGKS FRWASGLSRH VRVHSGETTF KCEECGKGFY TNSQRYSHQR
   421  AHSGEKPYRC EECGKGYKRR LDLDFHQRVH RGEKPYNCKE CGKSFGWASC LLNHQRIHSG
   481  EKPFKCEECG KRFTQNSQLY THRRVHSGEK PFKCEECGKR FTQNSQLYSH RRVHTGVKPY
   541  KCEECGKGFN SKFNLDMHQR VHTGERPYNC KECGKSFSRA SSILNHKRLH GDEKPFKCEE
   601  CGKRFTENSQ LHSHQRVHTG EKPYKCEKCG KSFRWASTHL THQRLHSREK LLQCEDCGKS
   661  IVHSSCLKDQ QRDQSGEKTS KCEDCGKRYK RRLNLDTLLS LFLNDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF225 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
breast: 7.7 nTPM
retina: 6.4 nTPM
thymus: 4.9 nTPM
ovary: 4.6 nTPM
parathyroid gland: 4.2 nTPM

Single-cell type

cardiomyocytes: 39 nCPM
late primary spermatocytes: 13 nCPM
retinal pigment epithelial cells: 13 nCPM
choroid plexus epithelial cells: 8.3 nCPM
distal convoluted tubule cells: 7.3 nCPM
early spermatids: 6.4 nCPM

Immune cell

basophil: 12 nTPM
naive B-cell: 5.4 nTPM
eosinophil: 5.2 nTPM
naive CD4 T-cell: 4.7 nTPM
intermediate monocyte: 4.6 nTPM
myeloid DC: 4.4 nTPM

Brain region

white matter: 16 nTPM
basal ganglia: 13 nTPM
cerebellum: 13 nTPM
midbrain: 12 nTPM
cerebral cortex: 12 nTPM
medulla oblongata: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0.11
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF225 as an antibody target. Whether an autoantibody or antibody against ZNF225 could matter depends on whether native ZNF225 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF225 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF225 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...