Seroatlas · Human Serome Atlas

ZNF223

Zinc finger protein 223

Also known as: ZN223_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UK11
Gene: ZNF223
Ensembl: ENSG00000178386
Chromosome: 19
Canonical length: 482 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q9UK11|ZNF223
     1  MTMSKEAVTF KDVAVVFTEE ELGLLDLAQR KLYRDVMLEN FRNLLSVGHQ PFHRDTFHFL
    61  REEKFWMMDI ATQREGNSGG KIQPEMKTFP EAGPHEGWSC QQIWEEIASD LTRPQDSTIK
   121  SSQFFEQGDA HSQVEEGLSI MHTGQKPSNC GKCKQSFSDM SIFDLPQQIR SAEKSHSCDE
   181  CGKSFCYISA LHIHQRVHLG EKLFKCDVCG KEFSQSLHLQ THQRVHTGEK PFKCEQCGRG
   241  FRCRSALTVH CKLHMGEKHY NCEACGRAFI HDFQLQKHQR IHTGEKPFKC EICSVSFRLR
   301  SSLNRHCVVH TGKKPNSTGE YGKGFIRRLD LCKHQTIHTG EKPYNCKECG KSFRRSSYLL
   361  IHQRVHTGEK PYKCDKCGKS YITKSGLDLH HRAHTGERPY NCDDCGKSFR QASSILNHKR
   421  LHCRKKPFKC EDCGKKLVYR SYRKDQQKNH SGENPSKCED CGKRYKRRLN LDIILSLFLN
   481  DT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF223 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 6.1 nTPM

Expression across tissuesHPA

Tissue

prostate: 6.1 nTPM
thyroid gland: 5.9 nTPM
epididymis: 5.6 nTPM
rectum: 5.4 nTPM
breast: 5.1 nTPM
placenta: 5.1 nTPM

Single-cell type

other brain neurons: 11 nCPM
brain excitatory neurons: 10 nCPM
brain inhibitory neurons: 9.5 nCPM
bergmann glia: 8.1 nCPM
oligodendrocyte progenitor cells: 8.1 nCPM
microglia: 6.9 nCPM

Immune cell

basophil: 15 nTPM
eosinophil: 7.8 nTPM
naive CD4 T-cell: 7.4 nTPM
plasmacytoid DC: 6.7 nTPM
NK-cell: 6.2 nTPM
intermediate monocyte: 5.9 nTPM

Brain region

cerebellum: 10 nTPM
cerebral cortex: 9.8 nTPM
hypothalamus: 9.1 nTPM
pons: 8.5 nTPM
thalamus: 8.5 nTPM
white matter: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF223 as an antibody target. Whether an autoantibody or antibody against ZNF223 could matter depends on whether native ZNF223 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF223 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF223 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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