Seroatlas · Human Serome Atlas

ZNF222

Zinc finger protein 222

Also known as: ZN222_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UK12
Gene: ZNF222
Ensembl: ENSG00000159885
Chromosome: 19
Canonical length: 451 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>Q9UK12|ZNF222
     1  MAKLYEAVTF KDVAVIFTEE ELGLLDPAQR KLYRDVMLEN FRNLLSVGGK IQTEMETVPE
    61  AGTHEEFSCK QIWEQIASDL TRSQDTTISN SQLFEQDDNP SQIKARLSTV HTREKPFQGE
   121  NCKQFFSDVS FFDLPQQLYS GEKSHTCDEC GKSFCYISAL HIHQRVHMGV KCYKCDVCGK
   181  EFSQSSRLQT HQRVHTGEKP FKCEQCGKGF RCRSALKVHC KLHMREKPYN CEKCGKAFMH
   241  NFQLQKHHRI HTGEKPFKCE ICGKSFCLRS SLNRHCMVHT AEKLYKSEKY GRGFIDRLDL
   301  HKHQMIHMGQ KPYNCKECGK SFKWSSYLLV HQRVHTGEKP YKCEECGKGY ISKSGLDFHH
   361  RTHTGERSYN CDNCGKSFRH ASSILNHKKL HCQRKPLKCE DCGKRLVCRS YCKDQQRDHS
   421  GENPSKCEDC GKRYKRRLNL DIILSLFLND I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF222 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 8.5 nTPM

Expression across tissuesHPA

Tissue

testis: 8.5 nTPM
cerebellum: 6.8 nTPM
retina: 6.3 nTPM
thymus: 5.4 nTPM
bone marrow: 5 nTPM
pituitary gland: 4.9 nTPM

Single-cell type

other brain neurons: 6 nCPM
oligodendrocyte progenitor cells: 4.7 nCPM
brain inhibitory neurons: 4.5 nCPM
brain excitatory neurons: 4.3 nCPM
bergmann glia: 3.6 nCPM
choroid plexus epithelial cells: 3.1 nCPM

Immune cell

basophil: 7.8 nTPM
naive CD4 T-cell: 6.2 nTPM
gdT-cell: 6 nTPM
naive B-cell: 6 nTPM
memory CD8 T-cell: 5.7 nTPM
memory CD4 T-cell: 5.4 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 8.5 nTPM
midbrain: 8.3 nTPM
pons: 8 nTPM
hypothalamus: 7.9 nTPM
medulla oblongata: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF222 as an antibody target. Whether an autoantibody or antibody against ZNF222 could matter depends on whether native ZNF222 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF222 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF222 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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