Seroatlas · Human Serome Atlas

ZNF221

Zinc finger protein 221

Also known as: ZN221_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UK13
Gene: ZNF221
Ensembl: ENSG00000159905
Chromosome: 19
Canonical length: 617 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>Q9UK13|ZNF221
     1  MISPSLELLH SGLCKFPEVE GKMTTFKEAV TFKDVAVVFT EEELGLLDPA QRKLYRDVML
    61  ENFRNLLSVG NQPFHQDTFH FLGKEKFWKM KTTSQREGNS GGKIQIEMET VPEAGPHEEW
   121  SCQQIWEQIA SDLTRSQNSI RNSSQFFKEG DVPCQIEARL SISHVQQKPY RCNECKQSFS
   181  DVSVFDLHQQ SHSGEKSHTC GECGKSFCYS PALHIHQRVH MGEKCYKCDV CGKEFNQSSH
   241  LQTHQRVHTG EKPFKCGQCG KGFHSRSALN VHCKLHTGEK PYNCEECGKA FIHDSQLQEH
   301  QRIHTGEKPF KCDICGKSFR VRSRLNRHSM VHTGEKPFRC DTCGKNFRQR SALNSHSMVH
   361  IEEKPYKCEQ CGKGFICRRD FCKHQMVHTG EKPYNCKECG KTFRWSSCLL NHQQVHSGQK
   421  SFKCEECGKG FYTNSRRSSH QRSHNGEKPY NCEECGKDYK RRLDLEFHQR VHTGERPYNC
   481  KECGKSFGWA SCLLKHQRLH SGEKPFKCEE CGKRFTQSSQ LHSHQTCHTG EKLYKCEQCE
   541  KGYNSKFNLD MHQRVHGGER PYNCKECGKS FGWASCLLKH QRLHSGEKPL KSGVWEEIYS
   601  EFTASFTSVS LCGRKAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF221 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

retina: 2.7 nTPM
cerebellum: 2.2 nTPM
parathyroid gland: 2.1 nTPM
thyroid gland: 1.7 nTPM
cerebral cortex: 1.4 nTPM
ovary: 1.4 nTPM

Single-cell type

cardiomyocytes: 11 nCPM
choroid plexus epithelial cells: 8.9 nCPM
lactotrophs: 7.3 nCPM
fibro-adipogenic progenitors: 6.7 nCPM
thyrotrophs: 6.7 nCPM
somatotrophs: 6.1 nCPM

Immune cell

NK-cell: 0.6 nTPM
basophil: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
myeloid DC: 0.3 nTPM
neutrophil: 0.3 nTPM

Brain region

cerebellum: 18 nTPM
white matter: 15 nTPM
pons: 12 nTPM
thalamus: 12 nTPM
hypothalamus: 11 nTPM
basal ganglia: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.42
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF221 as an antibody target. Whether an autoantibody or antibody against ZNF221 could matter depends on whether native ZNF221 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF221 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF221 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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