Seroatlas · Human Serome Atlas

ZNF22-AS1

Uncharacterized protein ZNF22-AS1

Also known as: ZFAS1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T742
Gene: ZNF22-AS1
Canonical length: 122 aa

OverviewNCBI Gene

No narrative summary is available for ZNF22-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>Q5T742|ZNF22-AS1
     1  MVPGPPESVV RFFLWFCFLL PPTRKASCDP RDLKSCNRPC VWSRLLKPNS SLSNLETAYF
    61  PQILRFLRPW YFSRSHLNYH QKAPARWEWL YSIYRKGTKA QRRNVLRSPC APPQPSWPCS
   121  VI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF22-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF22-AS1 as an antibody target. Whether an autoantibody or antibody against ZNF22-AS1 could matter depends on whether native ZNF22-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF22-AS1 is annotated as secreted, so native ZNF22-AS1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ZNF22-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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