Seroatlas · Human Serome Atlas

ZNF22

Zinc finger protein 22

Also known as: HKR-T1, KOX15, Zfp422, ZNF22_HUMAN, ZNF422

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17026
Gene: ZNF22
Ensembl: ENSG00000165512
Chromosome: 10
Canonical length: 224 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity. Predicted to be involved in regulation of gene expression. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>P17026|ZNF22
     1  MRLAKPKAGI SRSSSQGKAY ENKRKTGRQR QKWGMTIRFD SSFSRLRRSL DDKPYKCTEC
    61  EKSFSQSSTL FQHQKIHTGK KSHKCADCGK SFFQSSNLIQ HRRIHTGEKP YKCDECGESF
   121  KQSSNLIQHQ RIHTGEKPYQ CDECGRCFSQ SSHLIQHQRT HTGEKPYQCS ECGKCFSQSS
   181  HLRQHMKVHK EEKPRKTRGK NIRVKTHLPS WKAGTGRKSV AGLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

thymus: 66 nTPM
ovary: 39 nTPM
breast: 38 nTPM
placenta: 38 nTPM
pancreas: 37 nTPM
liver: 36 nTPM

Single-cell type

megakaryocytes: 124 nCPM
megakaryocyte-erythroid progenitors: 111 nCPM
hepatic stellate cells: 110 nCPM
megakaryocyte progenitors: 97 nCPM
migrating cytotrophoblasts: 89 nCPM
hematopoietic stem cells: 84 nCPM

Immune cell

NK-cell: 71 nTPM
plasmacytoid DC: 65 nTPM
MAIT T-cell: 63 nTPM
naive CD8 T-cell: 57 nTPM
naive B-cell: 55 nTPM
memory CD8 T-cell: 54 nTPM

Brain region

medulla oblongata: 25 nTPM
white matter: 19 nTPM
spinal cord: 16 nTPM
basal ganglia: 16 nTPM
thalamus: 16 nTPM
hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF22 as an antibody target. Whether an autoantibody or antibody against ZNF22 could matter depends on whether native ZNF22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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